Amiloride hydrochloride: pyrazinoylguanidine diuretic.
Amiloride hydrochloride testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.
Amiloride hydrochloride: 2D structure drawn from the PubChem record (CID 16231).
2609-46-3
C6H8ClN7O
229.63 g/mol
Pyrazinoylguanidine diuretic
Identity: Amiloride (free base)
IUPAC name: 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide
Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.
The USP monograph covers identity by infrared spectroscopy, HPLC retention time and a chloride test, assay by HPLC, organic impurities by HPLC, and residue on ignition, acidity by titration and water. Full testing to the USP Amiloride Hydrochloride monograph is available and quoted.
Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.
| Add-on test | Price |
|---|---|
| Identity and impurities | |
| FTIR identity | $90 |
| CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur) | $125 |
| Chiral purity (where a chiral method exists; new methods quoted) | $250 |
| Water, solvents and salt form | |
| Water content by Karl Fischer | $60 |
| Residual solvents | $150 |
| Counterions: chloride, acetate and TFA | $70 |
| Assay | |
| Assay, % w/w (with raw powder purity; $250 together) | +$50 |
| Metals and conformity | |
| Heavy metals: arsenic, cadmium, chromium, mercury and lead | $150 |
| Conformity: purity and quantity on more units from the same lot | $100 per extra unit |
| Microbiology (injectables) | |
| Endotoxin | $210 |
| Sterility or bioburden | $150 |
| Container closure integrity (CCI) | $50 |
| Screening | |
| Fentanyl screen | $50 |
10% off for 10 or more samples.
Need something else? Other tests are available on request.
Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.
No. The $250 test covers identity, purity and quantity by HPLC with UV detection for purity and assay, and LC-MS for identity. Full testing to the USP Amiloride Hydrochloride monograph is available and quoted.
The USP material is the dihydrate, and its water makes up a noticeable share of the weight. Results can be reported on the dihydrate, anhydrous salt or free base basis, so tell us which you need.
Its aminopyrazine ring absorbs strongly in the UV and near visible range, which gives the yellow color. That strong absorbance also makes HPLC-UV a sensitive way to measure it.
https://pubchem.ncbi.nlm.nih.gov/compound/16231
Identity facts from the USP monograph header for this compound.
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