Aminosalicylic acid (PAS)

Aminosalicylic acid: aminosalicylate (4-aminosalicylic acid).

Aminosalicylic acid testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Aminosalicylic acid: 2D structure drawn from the PubChem record (CID 4649).

Compound data

CAS number

65-49-6

Formula

C₇H₇NO₃

Molecular weight

153.14 g/mol

Type

Aminosalicylate (4-aminosalicylic acid)

Structure and names

Identity: Aminosalicylic acid

IUPAC name: 4-amino-2-hydroxybenzoic acid

How Vanguard tests Aminosalicylic acid

Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by UV, a color test and the melting point of a derivative, assay by HPLC, an m-aminophenol limit by HPLC, and residue on ignition, chloride and sulfate, pH, water and appearance tests. Full testing to the USP Aminosalicylic Acid monograph is available and quoted.

What's reported

Purity, as percent of total peak area
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit
Microbiology (injectables)
Endotoxin	$210
Sterility or bioburden	$150
Container closure integrity (CCI)	$50
Screening
Fentanyl screen	$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Aminosalicylic Acid (CAS 65-49-6)
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Aminosalicylic acid testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC with UV detection for purity and assay, and LC-MS for identity. Full testing to the USP Aminosalicylic Acid monograph is available and quoted.

What does aminosalicylic acid break down to?

It loses carbon dioxide on heating or in moist conditions and forms 3-aminophenol. That breakdown product is the main impurity the purity run looks for.

Why do some samples turn brown?

Aminosalicylic acid darkens in light, air and moisture as it decomposes. A brown or purple tint usually means 3-aminophenol and colored oxidation products are present.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/4649

Identity facts from the USP monograph header for this compound.

Order

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