Amodiaquine

Amodiaquine: 4-Aminoquinoline antimalarial.

Amodiaquine testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Amodiaquine: 2D structure drawn from the PubChem record (CID 2165).

Compound data

CAS number

86-42-0

Formula

C₂₀H₂₂ClN₃O

Molecular weight

355.86 g/mol

Type

4-Aminoquinoline antimalarial

Structure and names

Identity: Amodiaquine

IUPAC name: 4-[(7-chloroquinolin-4-yl)amino]-2-(diethylaminomethyl)phenol

How Vanguard tests Amodiaquine

Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by infrared and UV spectroscopy, assay by UV spectrophotometry, organic impurities by TLC, and residue on ignition and water. Full testing to the USP Amodiaquine monograph is available and quoted.

What's reported

Purity, as percent of total peak area
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit
Microbiology (injectables)
Endotoxin	$210
Sterility or bioburden	$150
Container closure integrity (CCI)	$50
Screening
Fentanyl screen	$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Amodiaquine (CAS 86-42-0)
Amodiaquine Hydrochloride
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Amodiaquine testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC with UV detection for purity and assay, and LC-MS for identity. Full testing to the USP Amodiaquine monograph is available and quoted.

Is amodiaquine tested as the base or the hydrochloride?

USP has monographs for both the base and the hydrochloride, which is a dihydrate salt with a much higher molecular weight. Tell us which form you have so the result is reported on the right basis.

Does the HPLC test add anything to the monograph method?

The monograph assays by UV, which reads total absorbance and cannot separate impurities. HPLC separates amodiaquine from related substances before it is measured.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/2165

Identity facts from the USP monograph header for this compound.

Order

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