Amprolium

Amprolium: thiamine analog coccidiostat (veterinary).

Amprolium testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Amprolium: 2D structure drawn from the PubChem record (CID 8732).

Compound data

CAS number

137-88-2

Formula

C₁₄H₁₉ClN₄ · HCl

Molecular weight

315.24 g/mol

Type

Thiamine analog coccidiostat (veterinary)

Structure and names

Identity: Amprolium hydrochloride

IUPAC name: 5-[(2-methylpyridin-1-ium-1-yl)methyl]-2-propylpyrimidin-4-amine;chloride;hydrochloride

How Vanguard tests Amprolium

Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monographs cover identity by infrared and UV spectroscopy, assay by HPLC, and loss on drying. Full testing to the USP Amprolium monograph is available and quoted.

What's reported

Purity, as percent of total peak area
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit
Microbiology (injectables)
Endotoxin	$210
Sterility or bioburden	$150
Container closure integrity (CCI)	$50
Screening
Fentanyl screen	$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Amprolium (CAS 137-88-2)
Amprolium Soluble Powder
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Amprolium testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC with UV detection for purity and assay, and LC-MS for identity. Full testing to the USP Amprolium monograph is available and quoted.

Can amprolium be confused with thiamine?

Amprolium is a structural analog of thiamine and shares its aminopyrimidine group. They differ in mass and retention time, so LC-MS and HPLC tell them apart.

Can the soluble powder be tested?

Yes. The soluble powder is dissolved and amprolium is measured against the label claim, with any carrier sugars left behind by the HPLC run.

Does the monograph include an impurity test?

No. The USP amprolium monographs have no organic impurities section. The HPLC purity run still shows related substances as area percent.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/8732

Identity facts from the USP monograph header for this compound.

Order

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