Anthralin (dithranol)

Anthralin: anthrone (dithranol).

Anthralin testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Anthralin: 2D structure drawn from the PubChem record (CID 2202).

Compound data

CAS number

1143-38-0

Formula

C₁₄H₁₀O₃

Molecular weight

226.23 g/mol

Type

Anthrone (dithranol)

Structure and names

Identity: Anthralin

IUPAC name: 1,8-dihydroxy-10H-anthracen-9-one

How Vanguard tests Anthralin

Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by infrared and UV spectroscopy, assay by HPLC, and residue on ignition, chloride and sulfate limits, loss on drying, acidity or alkalinity and melting range. Full testing to the USP Anthralin monograph is available and quoted.

What's reported

Purity, as percent of total peak area
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit
Microbiology (injectables)
Endotoxin	$210
Sterility or bioburden	$150
Container closure integrity (CCI)	$50
Screening
Fentanyl screen	$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Anthralin (CAS 1143-38-0)
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Anthralin testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC with UV detection for purity and assay, and LC-MS for identity. Full testing to the USP Anthralin monograph is available and quoted.

Why does anthralin turn brown?

Anthralin oxidizes easily in air and light, forming danthron and a brown dimer. These breakdown products separate on the HPLC run, so a darker sample often shows lower purity.

Does the monograph include a chromatographic impurity test?

No. Its impurity tests are inorganic and physical, so the HPLC purity run adds a view of oxidation products that the monograph does not separate.

Can anthralin be tested in a cream or ointment?

Yes. It is extracted from the base and measured, but it is unstable once dissolved, so extraction and analysis are done quickly and protected from light.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/2202

Identity facts from the USP monograph header for this compound.

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