Apraclonidine hydrochloride: alpha-2 adrenergic agonist (clonidine derivative).
Apraclonidine hydrochloride testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.
Apraclonidine hydrochloride: 2D structure drawn from the PubChem record (CID 51763).
73218-79-8
C9H10Cl2N4 · HCl
281.57 g/mol
Alpha-2 adrenergic agonist (clonidine derivative)
Identity: Apraclonidine hydrochloride
IUPAC name: 2,6-dichloro-1-N-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine;hydrochloride
Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.
The USP monograph covers identity by infrared spectroscopy and a chloride test, assay by nonaqueous potentiometric titration, chromatographic purity by HPLC, and pH, loss on drying and residue on ignition. Full testing to the USP Apraclonidine Hydrochloride monograph is available and quoted.
Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.
| Add-on test | Price |
|---|---|
| Identity and impurities | |
| FTIR identity | $90 |
| CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur) | $125 |
| Chiral purity (where a chiral method exists; new methods quoted) | $250 |
| Water, solvents and salt form | |
| Water content by Karl Fischer | $60 |
| Residual solvents | $150 |
| Counterions: chloride, acetate and TFA | $70 |
| Assay | |
| Assay, % w/w (with raw powder purity; $250 together) | +$50 |
| Metals and conformity | |
| Heavy metals: arsenic, cadmium, chromium, mercury and lead | $150 |
| Conformity: purity and quantity on more units from the same lot | $100 per extra unit |
| Microbiology (injectables) | |
| Endotoxin | $210 |
| Sterility or bioburden | $150 |
| Container closure integrity (CCI) | $50 |
| Screening | |
| Fentanyl screen | $50 |
10% off for 10 or more samples.
Need something else? Other tests are available on request.
Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.
No. The $250 test covers identity, purity and quantity by HPLC with UV detection for purity and assay, and LC-MS for identity. Full testing to the USP Apraclonidine Hydrochloride monograph is available and quoted.
Apraclonidine is clonidine with an added amino group on the ring, so it is 15 mass units heavier. LC-MS and HPLC retention time tell the two apart.
Yes. The drops are diluted and measured directly, and the result is reported as apraclonidine base or hydrochloride per mL, whichever matches the label.
https://pubchem.ncbi.nlm.nih.gov/compound/51763
Identity facts from the USP monograph header for this compound.
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