Artemether

Artemether: artemisinin derivative antimalarial.

Artemether testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Artemether: 2D structure drawn from the PubChem record (CID 68911).

Compound data

CAS number

71963-77-4

Formula

C₁₆H₂₆O₅

Molecular weight

298.37 g/mol

Type

Artemisinin derivative antimalarial

Structure and names

Identity: Artemether

IUPAC name: (1R,4S,5R,8S,9R,10S,12R,13R)-10-methoxy-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecane

How Vanguard tests Artemether

Method for the $250 identity, purity and quantity test: Chromatographic assay, with detection selected for the compound, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by infrared spectroscopy and HPLC retention time, assay by HPLC, organic impurities by HPLC, residue on ignition, and optical rotation. Full testing to the USP Artemether monograph is available and quoted.

What's reported

Purity, as percent of total peak area
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit
Microbiology (injectables)
Endotoxin	$210
Sterility or bioburden	$150
Container closure integrity (CCI)	$50
Screening
Fentanyl screen	$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Artemether (CAS 71963-77-4)
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Artemether testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by a chromatographic assay, with detection selected for the compound. Full testing to the USP Artemether monograph is available and quoted.

Why is artemether hard to see by UV?

Artemether has no aromatic ring or conjugated system, so the lab uses a detection method suited to the compound.

Is artemether heat sensitive?

Artemether contains an endoperoxide bridge that breaks down with heat and acid, so the test avoids heating the sample. Samples should be kept cool.

How is artemether related to artemisinin?

Artemether is the methyl ether of dihydroartemisinin, which is made from artemisinin. Artemisinin and dihydroartemisinin are possible impurities and separate from artemether by HPLC.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/68911

Identity facts from the USP monograph header for this compound.

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