Atovaquone

Atovaquone: hydroxynaphthoquinone antiprotozoal.

Atovaquone testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Atovaquone: 2D structure drawn from the PubChem record (CID 74989).

Compound data

CAS number

95233-18-4

Formula

C₂₂H₁₉ClO₃

Molecular weight

366.84 g/mol

Type

Hydroxynaphthoquinone antiprotozoal

Structure and names

Identity: Atovaquone

IUPAC name: 3-[4-(4-chlorophenyl)cyclohexyl]-4-hydroxynaphthalene-1,2-dione

How Vanguard tests Atovaquone

Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by infrared spectroscopy and HPLC retention time, assay by HPLC, organic impurities by HPLC, residue on ignition, and water content. Full testing to the USP Atovaquone monograph is available and quoted.

What's reported

Purity, as percent of total peak area
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit
Microbiology (injectables)
Endotoxin	$210
Sterility or bioburden	$150
Container closure integrity (CCI)	$50
Screening
Fentanyl screen	$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Atovaquone (CAS 95233-18-4)
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Atovaquone testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and quantity and LC-MS for identity. Full testing to the USP Atovaquone monograph is available and quoted.

Does atovaquone have a cis isomer?

Atovaquone is the trans isomer about its cyclohexyl ring, and the cis isomer is a known related compound. The two have the same mass, so they are told apart by HPLC retention time.

What form do atovaquone samples usually come in?

Atovaquone is often supplied as raw powder or as an oral suspension. It is very poorly soluble in water, so suspensions are extracted with organic solvent before HPLC.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/74989

Identity facts from the USP monograph header for this compound.

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