Beclomethasone dipropionate

Beclomethasone dipropionate: corticosteroid (glucocorticoid ester).

Beclomethasone dipropionate testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

2D structure of Beclomethasone dipropionate

Beclomethasone dipropionate: 2D structure drawn from the PubChem record (CID 21700).

Compound data

CAS number

5534-09-8

Formula

C28H37ClO7

Molecular weight

521.04 g/mol

Type

Corticosteroid (glucocorticoid ester)

Structure and names

Identity: Beclomethasone dipropionate (anhydrous)

IUPAC name: [2-[(8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-propanoyloxy-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] propanoate

How Vanguard tests Beclomethasone dipropionate

Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by infrared spectroscopy, assay by HPLC, residue on ignition, optical rotation and loss on drying. Full testing to the USP Beclomethasone Dipropionate monograph is available and quoted.

What's reported

  • Purity, as percent of total peak area
  • Quantity, against the label claim
  • Identity, reported as match or no match against the reference standard
  • With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on testPrice
Identity and impurities
FTIR identity$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)$125
Chiral purity (where a chiral method exists; new methods quoted)$250
Water, solvents and salt form
Water content by Karl Fischer$60
Residual solvents$150
Counterions: chloride, acetate and TFA$70
Assay
Assay, % w/w (with raw powder purity; $250 together)+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead$150
Conformity: purity and quantity on more units from the same lot$100 per extra unit
Microbiology (injectables)
Endotoxin$210
Sterility or bioburden$150
Container closure integrity (CCI)$50
Screening
Fentanyl screen$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

  • Beclomethasone Dipropionate (CAS 5534-09-8)
  • Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Beclomethasone dipropionate testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC with UV detection for purity and assay, and LC-MS for identity. Full testing to the USP Beclomethasone Dipropionate monograph is available and quoted.

Can the test tell beclomethasone dipropionate from its monopropionates?

Yes. The 17- and 21-monopropionates and free beclomethasone differ in mass and retention time, so they show up separately in the purity profile.

Does the monohydrate give a different result?

Beclomethasone dipropionate is also supplied as a monohydrate, which carries a small amount of water and assays slightly lower on an as-is basis. Tell us which form is on the label.

What sample forms are common?

Powders, inhaler formulations, nasal sprays and creams. Creams and sprays need an extraction step, so send the labeled strength with the sample.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/21700

Identity facts from the USP monograph header for this compound.

Order

Start an order online, or send the compound name and the tests you need for a quote.