Calcium gluconate

Calcium gluconate: mineral salt (calcium).

Calcium gluconate testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Calcium gluconate: 2D structure drawn from the PubChem record (CID 9290).

Compound data

CAS number

299-28-5

Formula

C₁₂H₂₂CaO₁₄

Molecular weight

430.37 g/mol

Type

Mineral salt (calcium)

Structure and names

Identity: Calcium gluconate (anhydrous)

IUPAC name: calcium bis((2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate)

How Vanguard tests Calcium gluconate

Method for the $250 identity, purity and quantity test: ICP-MS metal content, HPLC assay of the gluconate counter-ion, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by a calcium test and infrared spectroscopy, assay by titration, arsenic, chloride, sulfate and phosphate limits, iron by ICP, magnesium and alkali metals, oxalate by ion chromatography, reducing substances by titration, and loss on drying. Full testing to the USP Calcium Gluconate monograph is available and quoted.

What's reported

Metal content by ICP-MS, against the label or specification
Purity, as percent of total peak area
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit
Microbiology (injectables)
Endotoxin	$210
Sterility or bioburden	$150
Container closure integrity (CCI)	$50
Screening
Fentanyl screen	$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Calcium Gluconate (anhydrous CAS 299-28-5; monohydrate CAS 66905-23-5)
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Calcium gluconate testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by ICP-MS for calcium and HPLC for the gluconate. Full testing to the USP Calcium Gluconate monograph is available and quoted.

Is calcium reported as elemental calcium or as calcium gluconate?

Either. Calcium gluconate holds a small share of calcium by weight, so labels often state elemental calcium. ICP-MS measures calcium directly and the result can be converted to the salt.

Why does the monograph test for oxalate?

Oxalate can be present from manufacturing and forms insoluble calcium oxalate. The USP monograph measures it by ion chromatography.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/9290

Identity facts from the USP monograph header for this compound.

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