Calcium pantothenate (vitamin B5)

Calcium pantothenate: water-soluble vitamin (B5).

Calcium pantothenate testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Calcium pantothenate: 2D structure drawn from the PubChem record (CID 443753).

Compound data

CAS number

137-08-6

Formula

C₁₈H₃₂CaN₂O₁₀

Molecular weight

476.53 g/mol

Type

Water-soluble vitamin (B5)

Structure and names

Identity: Calcium pantothenate

IUPAC name: calcium bis(3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]propanoate)

How Vanguard tests Calcium pantothenate

Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monographs cover identity by infrared spectroscopy, a calcium test and optical rotation, assay by HPLC (by nitrogen determination and calcium titration for the racemic form), other related substances by HPLC, beta-alanine and related impurities by titration, alkalinity, and loss on drying. Full testing to the USP Calcium Pantothenate monograph is available and quoted.

What's reported

Purity, as percent of total peak area
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Calcium Pantothenate (CAS 137-08-6)
Racemic Calcium Pantothenate (CAS 6381-63-1)
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Calcium pantothenate testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and quantity and LC-MS for identity. Full testing to the USP Calcium Pantothenate monograph is available and quoted.

What is the difference between calcium pantothenate and racemic calcium pantothenate?

Calcium pantothenate is the D form. The racemic form is an equal mix of D and L, so it carries half the D content per gram. Standard HPLC does not separate the two, so optical rotation or a chiral method is needed to tell them apart.

Is the result reported as pantothenic acid or as the calcium salt?

Either. The pantothenate is quantified by HPLC and the result can be converted to pantothenic acid or calcium pantothenate using the molecular weights.

Does pantothenate degrade?

With moisture and heat, pantothenate can hydrolyze to pantoic acid (pantolactone) and beta-alanine. Samples should be kept dry and sealed.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/443753

Identity facts from the USP monograph header for this compound.

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