Candesartan cilexetil

Candesartan cilexetil: angiotensin II receptor blocker (sartan ester prodrug).

Candesartan cilexetil testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Candesartan cilexetil: 2D structure drawn from the PubChem record (CID 2540).

Compound data

CAS number

145040-37-5

Formula

C₃₃H₃₄N₆O₆

Molecular weight

610.67 g/mol

Type

Angiotensin II receptor blocker (sartan ester prodrug)

Structure and names

Identity: Candesartan cilexetil

IUPAC name: 1-cyclohexyloxycarbonyloxyethyl 2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate

How Vanguard tests Candesartan cilexetil

Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by infrared spectroscopy and HPLC retention time, assay by HPLC, organic impurities by HPLC, residue on ignition, and water content. Full testing to the USP Candesartan Cilexetil monograph is available and quoted.

What's reported

Purity, as percent of total peak area
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit
Microbiology (injectables)
Endotoxin	$210
Sterility or bioburden	$150
Container closure integrity (CCI)	$50
Screening
Fentanyl screen	$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Candesartan Cilexetil (CAS 145040-37-5)
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Candesartan cilexetil testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and quantity and LC-MS for identity. Full testing to the USP Candesartan Cilexetil monograph is available and quoted.

What is the difference between candesartan and candesartan cilexetil?

Candesartan cilexetil is an ester of candesartan. It hydrolyzes to candesartan, which is a separate HPLC peak with a lower mass, so the test shows whether the ester has broken down.

Is candesartan cilexetil chiral?

The cilexetil group has one stereocenter, and the material is a racemic mixture. The standard HPLC test reports total candesartan cilexetil.

Does the $250 test look for nitrosamines?

No. Trace nitrosamines such as NDMA and NDEA, which can occur in sartans from some synthesis routes, need a dedicated LC-MS/MS or GC-MS method. That testing is quoted separately.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/2540

Identity facts from the USP monograph header for this compound.

Order

Start an order online, or send the compound name and the tests you need for a quote.

All research compounds