Carbidopa: aromatic amino acid decarboxylase inhibitor (hydrazine derivative).
Carbidopa testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.
Carbidopa: 2D structure drawn from the PubChem record (CID 38101).
38821-49-7
C10H14N2O4 · H2O
244.24 g/mol
Aromatic amino acid decarboxylase inhibitor (hydrazine derivative)
Identity: Carbidopa (monohydrate)
IUPAC name: (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid;hydrate
Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.
The USP monograph covers identity by infrared spectroscopy and HPLC retention time, assay by HPLC, organic impurities by HPLC, and optical rotation, loss on drying and residue on ignition. Full testing to the USP Carbidopa monograph is available and quoted.
Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.
| Add-on test | Price |
|---|---|
| Identity and impurities | |
| FTIR identity | $90 |
| CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur) | $125 |
| Chiral purity (where a chiral method exists; new methods quoted) | $250 |
| Water, solvents and salt form | |
| Water content by Karl Fischer | $60 |
| Residual solvents | $150 |
| Counterions: chloride, acetate and TFA | $70 |
| Assay | |
| Assay, % w/w (with raw powder purity; $250 together) | +$50 |
| Metals and conformity | |
| Heavy metals: arsenic, cadmium, chromium, mercury and lead | $150 |
| Conformity: purity and quantity on more units from the same lot | $100 per extra unit |
| Microbiology (injectables) | |
| Endotoxin | $210 |
| Sterility or bioburden | $150 |
| Container closure integrity (CCI) | $50 |
| Screening | |
| Fentanyl screen | $50 |
10% off for 10 or more samples.
Need something else? Other tests are available on request.
Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.
No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and assay, with LC-MS to confirm identity. Full testing to the USP Carbidopa monograph is available and quoted.
Carbidopa is usually supplied as the monohydrate, which is about 8% heavier than the anhydrous form. Results are reported against the labeled form.
Hydrazine is a known carbidopa degradation product. It is not seen well by HPLC-UV purity testing, so a hydrazine test is quoted separately.
Yes. Carbidopa usually arrives combined with levodopa in tablets, and both can be quantified from the same sample; mixtures are quoted by the number of compounds.
https://pubchem.ncbi.nlm.nih.gov/compound/38101
Identity facts from the USP monograph header for this compound.
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