Carmustine

Carmustine: nitrosourea alkylating agent.

Carmustine testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Carmustine: 2D structure drawn from the PubChem record (CID 2578).

Compound data

CAS number

154-93-8

Formula

C₅H₉Cl₂N₃O₂

Molecular weight

214.05 g/mol

Type

Nitrosourea alkylating agent

Structure and names

Identity: Carmustine

IUPAC name: 1,3-bis(2-chloroethyl)-1-nitrosourea

How Vanguard tests Carmustine

Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by infrared spectroscopy and HPLC retention time, assay by HPLC, related compound A by HPLC, 2-chloroethylamine by thin-layer chromatography, 2-chloroethanol and acetaldehyde by gas chromatography, and ether-insoluble substances and water. Full testing to the USP Carmustine monograph is available and quoted.

What's reported

Purity, as percent of total peak area
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit
Microbiology (injectables)
Endotoxin	$210
Sterility or bioburden	$150
Container closure integrity (CCI)	$50
Screening
Fentanyl screen	$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Carmustine (CAS 154-93-8)
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Carmustine testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and assay, with LC-MS to confirm identity. Full testing to the USP Carmustine monograph is available and quoted.

How should carmustine samples be shipped?

Carmustine has a low melting point, around 30 degrees C, and degrades with heat and moisture. Samples should be shipped cold in a sealed container, and a sample that has melted or turned oily is likely degraded.

What is the main degradation product of carmustine?

Carmustine breaks down to 1,3-bis(2-chloroethyl)urea, listed by USP as a related compound. It shows up as a separate peak in the HPLC purity profile.

Why does the monograph use GC for some impurities?

Small volatile breakdown products such as 2-chloroethanol and acetaldehyde are better measured by gas chromatography. GC testing for these is available and quoted.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/2578

Identity facts from the USP monograph header for this compound.

Order

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