Cefepime hydrochloride: cephalosporin antibiotic (fourth generation).
Cefepime hydrochloride testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.
Cefepime hydrochloride: 2D structure drawn from the PubChem record (CID 5479537).
88040-23-7
C19H24N6O5S2
480.56 g/mol
Cephalosporin antibiotic (fourth generation)
Identity: Cefepime
IUPAC name: (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(1-methylpyrrolidin-1-ium-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.
The USP monograph covers identity by infrared spectroscopy, HPLC retention time and a chloride test, and assay by HPLC. Full testing to the USP Cefepime monograph is available and quoted.
Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.
| Add-on test | Price |
|---|---|
| Identity and impurities | |
| FTIR identity | $90 |
| CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur) | $125 |
| Chiral purity (where a chiral method exists; new methods quoted) | $250 |
| Water, solvents and salt form | |
| Water content by Karl Fischer | $60 |
| Residual solvents | $150 |
| Counterions: chloride, acetate and TFA | $70 |
| Assay | |
| Assay, % w/w (with raw powder purity; $250 together) | +$50 |
| Metals and conformity | |
| Heavy metals: arsenic, cadmium, chromium, mercury and lead | $150 |
| Conformity: purity and quantity on more units from the same lot | $100 per extra unit |
| Microbiology (injectables) | |
| Endotoxin | $210 |
| Sterility or bioburden | $150 |
| Container closure integrity (CCI) | $50 |
| Screening | |
| Fentanyl screen | $50 |
10% off for 10 or more samples.
Need something else? Other tests are available on request.
Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.
No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and assay, with LC-MS to confirm identity. Full testing to the USP Cefepime monograph is available and quoted.
Cefepime degrades in solution and releases N-methylpyrrolidine from its side chain, along with opened beta-lactam products. Samples are prepared fresh and breakdown products show up as extra HPLC peaks.
Cefepime hydrochloride powder for injection is blended with L-arginine to adjust pH. The assay is reported against cefepime, and the arginine does not interfere with the result.
USP expresses cefepime content on the anhydrous free base basis. Tell us if you need results on the hydrochloride salt as received.
https://pubchem.ncbi.nlm.nih.gov/compound/5479537
Identity facts from the USP monograph header for this compound.
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