Cefoxitin sodium

Cefoxitin sodium: cephamycin antibiotic (second generation).

Cefoxitin sodium testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

2D structure of Cefoxitin sodium

Cefoxitin sodium: 2D structure drawn from the PubChem record (CID 23667300).

Compound data

CAS number

33564-30-6

Formula

C16H16N3NaO7S2

Molecular weight

449.43 g/mol

Type

Cephamycin antibiotic (second generation)

Structure and names

Identity: Cefoxitin sodium

IUPAC name: sodium (6R,7S)-3-(carbamoyloxymethyl)-7-methoxy-8-oxo-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

How Vanguard tests Cefoxitin sodium

Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by HPLC retention time, UV spectroscopy and a sodium test, assay by HPLC, acetone and methanol by gas chromatography, and optical rotation, pH, water, bacterial endotoxins and sterility. Full testing to the USP Cefoxitin monograph is available and quoted.

What's reported

  • Purity, as percent of total peak area
  • Quantity, against the label claim
  • Identity, reported as match or no match against the reference standard
  • With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on testPrice
Identity and impurities
FTIR identity$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)$125
Chiral purity (where a chiral method exists; new methods quoted)$250
Water, solvents and salt form
Water content by Karl Fischer$60
Residual solvents$150
Counterions: chloride, acetate and TFA$70
Assay
Assay, % w/w (with raw powder purity; $250 together)+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead$150
Conformity: purity and quantity on more units from the same lot$100 per extra unit
Microbiology (injectables)
Endotoxin$210
Sterility or bioburden$150
Container closure integrity (CCI)$50
Screening
Fentanyl screen$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

  • Cefoxitin Sodium (CAS 33564-30-6)
  • Cefoxitin
  • Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Cefoxitin sodium testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and assay, with LC-MS to confirm identity. Full testing to the USP Cefoxitin monograph is available and quoted.

What is the main degradation product of cefoxitin?

Cefoxitin can lose its carbamoyl group to form decarbamoylcefoxitin, and the beta-lactam ring can open with moisture. These appear as separate peaks in the HPLC profile.

Why does the monograph test acetone and methanol?

These solvents can remain from crystallizing cefoxitin sodium. They are measured by GC, which is available and quoted.

Is cefoxitin sodium hygroscopic?

Yes. It picks up moisture from air, which affects both weight and stability, so samples should stay sealed until testing.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/23667300

Identity facts from the USP monograph header for this compound.

Order

Start an order online, or send the compound name and the tests you need for a quote.