Ceftizoxime sodium

Ceftizoxime sodium: cephalosporin antibiotic (third generation).

Ceftizoxime sodium testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Ceftizoxime sodium: 2D structure drawn from the PubChem record (CID 23663938).

Compound data

CAS number

68401-82-1

Formula

C₁₃H₁₂N₅NaO₅S₂

Molecular weight

405.38 g/mol

Type

Cephalosporin antibiotic (third generation)

Structure and names

Identity: Ceftizoxime sodium

IUPAC name: sodium (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

How Vanguard tests Ceftizoxime sodium

Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by HPLC and a sodium test, assay by HPLC, and pH, water, sterility and bacterial endotoxins. Full testing to the USP Ceftizoxime monograph is available and quoted.

What's reported

Purity, as percent of total peak area
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit
Microbiology (injectables)
Endotoxin	$210
Sterility or bioburden	$150
Container closure integrity (CCI)	$50
Screening
Fentanyl screen	$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Ceftizoxime Sodium (CAS 68401-82-1)
Ceftizoxime
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Ceftizoxime sodium testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and assay, with LC-MS to confirm identity. Full testing to the USP Ceftizoxime monograph is available and quoted.

How is ceftizoxime different from other cephalosporins structurally?

Ceftizoxime has no side chain at the 3 position of the cephem ring, so it does not release a side-chain breakdown product like cefotaxime does. Opened beta-lactam products still appear as separate HPLC peaks.

Is the result reported as ceftizoxime or the sodium salt?

USP expresses content as ceftizoxime. Tell us if you need the result on the sodium salt basis as labeled.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/23663938

Identity facts from the USP monograph header for this compound.

Order

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