Ceftriaxone sodium

Ceftriaxone sodium: cephalosporin antibiotic (third generation).

Ceftriaxone sodium testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Ceftriaxone sodium: 2D structure drawn from the PubChem record (CID 11953897).

Compound data

CAS number

104376-79-6

Formula

C₁₈H₁₆N₈Na₂O₇S₃ · 3½H₂O

Molecular weight

661.60 g/mol

Type

Cephalosporin antibiotic (third generation)

Structure and names

Identity: Ceftriaxone sodium (hemiheptahydrate)

IUPAC name: tetrasodium;bis((6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(2-methyl-6-oxido-5-oxo-1,2,4-triazin-3-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate);heptahydrate

How Vanguard tests Ceftriaxone sodium

Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by infrared spectroscopy, HPLC retention time and a sodium test, assay by HPLC, organic impurities by HPLC, and pH, water, sterility and bacterial endotoxins. Full testing to the USP Ceftriaxone monograph is available and quoted.

What's reported

Purity, as percent of total peak area
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit
Microbiology (injectables)
Endotoxin	$210
Sterility or bioburden	$150
Container closure integrity (CCI)	$50
Screening
Fentanyl screen	$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Ceftriaxone Sodium (CAS 104376-79-6)
Ceftriaxone
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Ceftriaxone sodium testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and assay, with LC-MS to confirm identity. Full testing to the USP Ceftriaxone monograph is available and quoted.

Why is ceftriaxone sodium listed with three and a half waters?

Ceftriaxone sodium crystallizes as a hemiheptahydrate. USP expresses content as ceftriaxone on the anhydrous basis, so water content is part of the calculation.

Which isomer impurity is typical for ceftriaxone?

The E isomer of the methoxyimino side chain is a known ceftriaxone related compound. It has the same mass as ceftriaxone and is separated by HPLC.

What forms does ceftriaxone arrive in?

Usually powder in vials or frozen premixed bags. Tell us which so the sample is handled and reconstituted correctly.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/11953897

Identity facts from the USP monograph header for this compound.

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