Cefuroxime: cephalosporin antibiotic (second generation).
Cefuroxime testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.
Cefuroxime: 2D structure drawn from the PubChem record (CID 6321416).
64544-07-6
C20H22N4O10S
510.47 g/mol
Cephalosporin antibiotic (second generation)
Identity: Cefuroxime axetil
IUPAC name: 1-acetyloxyethyl (6R,7R)-3-(carbamoyloxymethyl)-7-[[(2Z)-2-(furan-2-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.
The USP monograph covers identity by infrared spectroscopy and HPLC retention time, assay by HPLC, organic impurities by HPLC, and water and the diastereomer ratio by HPLC for cefuroxime axetil, and identity by HPLC and a sodium test, assay by HPLC, and pH, water, sterility and bacterial endotoxins for cefuroxime sodium. Full testing to the USP Cefuroxime Axetil monograph is available and quoted.
Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.
| Add-on test | Price |
|---|---|
| Identity and impurities | |
| FTIR identity | $90 |
| CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur) | $125 |
| Chiral purity (where a chiral method exists; new methods quoted) | $250 |
| Water, solvents and salt form | |
| Water content by Karl Fischer | $60 |
| Residual solvents | $150 |
| Counterions: chloride, acetate and TFA | $70 |
| Assay | |
| Assay, % w/w (with raw powder purity; $250 together) | +$50 |
| Metals and conformity | |
| Heavy metals: arsenic, cadmium, chromium, mercury and lead | $150 |
| Conformity: purity and quantity on more units from the same lot | $100 per extra unit |
| Microbiology (injectables) | |
| Endotoxin | $210 |
| Sterility or bioburden | $150 |
| Container closure integrity (CCI) | $50 |
| Screening | |
| Fentanyl screen | $50 |
10% off for 10 or more samples.
Need something else? Other tests are available on request.
Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.
No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and assay, with LC-MS to confirm identity. Full testing to the USP Cefuroxime Axetil monograph is available and quoted.
Cefuroxime axetil is an ester made for oral tablets and suspensions, while cefuroxime sodium is the salt used for injection. They have different molecular weights and are reported against the form on the label.
The axetil ester exists as two diastereomers, A and B, which separate on HPLC. Both are summed for the assay and their ratio is part of the USP monograph.
USP names the delta-3 isomers and the E isomers. They have the same mass as cefuroxime axetil and are separated by HPLC.
https://pubchem.ncbi.nlm.nih.gov/compound/6321416
Identity facts from the USP monograph header for this compound.
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