Cephapirin (sodium and benzathine)

Cephapirin: cephalosporin antibiotic (first generation, veterinary).

Cephapirin testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

2D structure of Cephapirin

Cephapirin: 2D structure drawn from the PubChem record (CID 23675312).

Compound data

CAS number

24356-60-3

Formula

C17H16N3NaO6S2

Molecular weight

445.45 g/mol

Type

Cephalosporin antibiotic (first generation, veterinary)

Structure and names

Identity: Cephapirin sodium

IUPAC name: sodium (6R,7R)-3-(acetyloxymethyl)-8-oxo-7-[(2-pyridin-4-ylsulfanylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

How Vanguard tests Cephapirin

Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by infrared spectroscopy and a sodium test, assay by HPLC, and pH, water, sterility and bacterial endotoxins for cephapirin sodium, with benzathine content added for cephapirin benzathine. Full testing to the USP Cephapirin Sodium monograph is available and quoted.

What's reported

  • Purity, as percent of total peak area
  • Quantity, against the label claim
  • Identity, reported as match or no match against the reference standard
  • With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on testPrice
Identity and impurities
FTIR identity$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)$125
Chiral purity (where a chiral method exists; new methods quoted)$250
Water, solvents and salt form
Water content by Karl Fischer$60
Residual solvents$150
Counterions: chloride, acetate and TFA$70
Assay
Assay, % w/w (with raw powder purity; $250 together)+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead$150
Conformity: purity and quantity on more units from the same lot$100 per extra unit
Microbiology (injectables)
Endotoxin$210
Sterility or bioburden$150
Container closure integrity (CCI)$50
Screening
Fentanyl screen$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

  • Cephapirin Sodium (CAS 24356-60-3)
  • Cephapirin Benzathine (CAS 97468-37-6)
  • Cephapirin Sodium Intramammary Infusion
  • Cephapirin Benzathine Intramammary Infusion
  • Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Cephapirin testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and assay, with LC-MS to confirm identity. Full testing to the USP Cephapirin Sodium monograph is available and quoted.

What is the difference between cephapirin sodium and cephapirin benzathine?

Cephapirin benzathine is a poorly soluble salt with two cephapirin units per benzathine, while the sodium salt dissolves readily. Their molecular weights differ widely, so results are reported against the form on the label.

Can intramammary infusions be tested?

Yes. Intramammary products are oily suspensions, so cephapirin is extracted from the oil base before HPLC and reported per syringe or per gram.

What is the main degradation product of cephapirin?

Cephapirin loses its acetyl group to form desacetylcephapirin, which appears as a separate peak in the HPLC profile.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/23675312

Identity facts from the USP monograph header for this compound.

Order

Start an order online, or send the compound name and the tests you need for a quote.