Cevimeline hydrochloride: muscarinic agonist (quinuclidine derivative).
Cevimeline hydrochloride testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.
Cevimeline hydrochloride: 2D structure drawn from the PubChem record (CID 73416227).
153504-70-2
C10H17NOS · HCl · ½H2O
244.78 g/mol
Muscarinic agonist (quinuclidine derivative)
Identity: Cevimeline hydrochloride (hemihydrate)
IUPAC name: bis((2S,5S)-2-methylspiro[1,3-oxathiolane-5,3′-1-azabicyclo[2.2.2]octane]);hydrate;dihydrochloride
Method for the $250 identity, purity and quantity test: Chromatographic assay, with detection selected for the compound, against a reference standard, with results in 3 to 5 business days.
The USP monograph covers identity by infrared spectroscopy, HPLC retention time and a chloride test, assay by HPLC, organic impurities by HPLC, and residue on ignition and water. Full testing to the USP Cevimeline monograph is available and quoted.
Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.
| Add-on test | Price |
|---|---|
| Identity and impurities | |
| FTIR identity | $90 |
| CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur) | $125 |
| Chiral purity (where a chiral method exists; new methods quoted) | $250 |
| Water, solvents and salt form | |
| Water content by Karl Fischer | $60 |
| Residual solvents | $150 |
| Counterions: chloride, acetate and TFA | $70 |
| Assay | |
| Assay, % w/w (with raw powder purity; $250 together) | +$50 |
| Metals and conformity | |
| Heavy metals: arsenic, cadmium, chromium, mercury and lead | $150 |
| Conformity: purity and quantity on more units from the same lot | $100 per extra unit |
| Microbiology (injectables) | |
| Endotoxin | $210 |
| Sterility or bioburden | $150 |
| Container closure integrity (CCI) | $50 |
| Screening | |
| Fentanyl screen | $50 |
10% off for 10 or more samples.
Need something else? Other tests are available on request.
Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.
No. The $250 test covers identity, purity and quantity by a chromatographic assay, with detection selected for the compound. Full testing to the USP Cevimeline monograph is available and quoted.
Cevimeline is the cis isomer of a spiro compound, and the trans isomer is a possible related substance. The two have the same mass and are separated by HPLC.
USP describes the hydrochloride hemihydrate. Results are reported on that basis unless you ask for the free base, which is about 81 percent of the salt by weight.
Usually powder or capsules. Capsule contents are extracted and reported per capsule.
https://pubchem.ncbi.nlm.nih.gov/compound/73416227
Identity facts from the USP monograph header for this compound.
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