Cilastatin sodium: renal dehydropeptidase inhibitor.
Cilastatin sodium testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.
Cilastatin sodium: 2D structure drawn from the PubChem record (CID 23663403).
81129-83-1
C16H25N2NaO5S
380.43 g/mol
Renal dehydropeptidase inhibitor
Identity: Cilastatin sodium
IUPAC name: sodium (Z)-7-[(2R)-2-amino-2-carboxyethyl]sulfanyl-2-[[(1S)-2,2-dimethylcyclopropanecarbonyl]amino]hept-2-enoate
Method for the $250 identity, purity and quantity test: Chromatographic assay, with detection selected for the compound, against a reference standard, with results in 3 to 5 business days.
The USP monograph covers identity by HPLC retention time and a sodium flame test, assay by potentiometric titration, chromatographic purity by HPLC, residual solvents, and specific rotation, pH, water, bacterial endotoxins and sterility. Full testing to the USP Cilastatin monograph is available and quoted.
Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.
| Add-on test | Price |
|---|---|
| Identity and impurities | |
| FTIR identity | $90 |
| CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur) | $125 |
| Chiral purity (where a chiral method exists; new methods quoted) | $250 |
| Water, solvents and salt form | |
| Water content by Karl Fischer | $60 |
| Residual solvents | $150 |
| Counterions: chloride, acetate and TFA | $70 |
| Assay | |
| Assay, % w/w (with raw powder purity; $250 together) | +$50 |
| Metals and conformity | |
| Heavy metals: arsenic, cadmium, chromium, mercury and lead | $150 |
| Conformity: purity and quantity on more units from the same lot | $100 per extra unit |
| Microbiology (injectables) | |
| Endotoxin | $210 |
| Sterility or bioburden | $150 |
| Container closure integrity (CCI) | $50 |
| Screening | |
| Fentanyl screen | $50 |
10% off for 10 or more samples.
Need something else? Other tests are available on request.
Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.
No. The $250 test covers identity, purity and quantity by a chromatographic assay, with detection selected for the compound. Full testing to the USP Cilastatin monograph is available and quoted.
Yes. The two compounds separate by HPLC, so each can be quantified in the same run against its own reference standard and reported against the label claim.
Cilastatin is the Z isomer of its double bond. The E isomer is a known related compound and appears as a separate peak in the HPLC purity profile.
Cilastatin has only a weak UV chromophore, so the lab uses a detection method suited to the compound.
https://pubchem.ncbi.nlm.nih.gov/compound/23663403
Identity facts from the USP monograph header for this compound.
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