Clavulanate (clavulanate potassium)

Clavulanate: beta-lactamase inhibitor.

Purity and quantity by the chromatographic method matched to the compound (HPLC-UV, LC-MS or GC-MS), with identity against a reference standard. $250 per sample; raw powder purity $200. Results in 3 to 5 business days.

Structure

2D structure of Clavulanate

Clavulanate: 2D structure drawn from the PubChem record (CID 23665591).

Compound data

CAS number

61177-45-5 (potassium salt)

Formula

C8H8KNO5

Molecular weight

237.25 g/mol (monoisotopic 237.00)

Type

beta-lactamase inhibitor

Structure and names

IUPAC name: potassium (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylate

Other names: clavulanic acid, potassium clavulanate

How Vanguard tests Clavulanate

Identity, purity and quantity are measured by the chromatographic method matched to the compound (HPLC-UV, LC-MS or GC-MS) against a reference standard, $250 per sample with results in 3 to 5 business days.

Full testing to the USP Clavulanate Potassium monograph is available and quoted: identification by HPLC retention time against the USP reference standard and assay by HPLC with UV detection.

What's reported

  • Purity, as percent of total peak area
  • Quantity, in mg per unit or % w/w against the label
  • Identity, reported as match or no match against the reference standard
  • With full monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on testPrice
Identity and impurities
FTIR identity$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)$125
Chiral purity (where a chiral method exists; new methods quoted)$250
Water, solvents and salt form
Water content by Karl Fischer$60
Residual solvents$150
Counterions: chloride, acetate and TFA$70
Assay
Assay, % w/w (with raw powder purity; $250 together)+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead$150
Conformity: purity and quantity on more units from the same lot$100 per extra unit
Microbiology (injectables)
Endotoxin$210
Sterility or bioburden$150
Container closure integrity (CCI)$50
Screening
Fentanyl screen$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days.

Salts, forms and compendial references

  • A USP monograph exists for Clavulanate Potassium. Full monograph testing is quoted.
  • Tell us the salt or form the label states, so quantity is reported on the same basis.
  • One page covers Clavulanate and its salts and forms.

Questions about Clavulanate testing

Does clavulanate break down in storage?

Yes. Clavulanate potassium is hygroscopic and degrades with moisture and heat, so send it sealed and dry; its breakdown products separate by HPLC.

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity against a reference standard. Full testing to the USP Clavulanate Potassium monograph adds the monograph's own tests and is quoted.

Other USP titles on this page

USP monographs also exist for these clavulanate titles. The $250 identity, purity and quantity test applies to each; testing to the monograph for any of them is available and quoted. Tell us the title your specification names.

  • Clavulanic Acid

Order

Start an order online, or send the compound name and the tests you need for a quote.