Clioquinol

Clioquinol: halogenated 8-hydroxyquinoline (antimicrobial).

Clioquinol testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Clioquinol: 2D structure drawn from the PubChem record (CID 2788).

Compound data

CAS number

130-26-7

Formula

C₉H₅ClINO

Molecular weight

305.50 g/mol

Type

Halogenated 8-hydroxyquinoline (antimicrobial)

Structure and names

Identity: Clioquinol

IUPAC name: 5-chloro-7-iodoquinolin-8-ol

How Vanguard tests Clioquinol

Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by gas chromatography retention time, UV spectroscopy and a color test, assay by gas chromatography with flame ionization detection, free iodine and iodide limits, and loss on drying and residue on ignition. Full testing to the USP Clioquinol monograph is available and quoted.

What's reported

Purity, as percent of total peak area
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit
Microbiology (injectables)
Endotoxin	$210
Sterility or bioburden	$150
Container closure integrity (CCI)	$50
Screening
Fentanyl screen	$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Clioquinol (CAS 130-26-7)
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Clioquinol testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and assay, with LC-MS to confirm identity. Full testing to the USP Clioquinol monograph is available and quoted.

The USP monograph uses gas chromatography. Why does the $250 test use HPLC?

Clioquinol has a strong UV chromophore, so HPLC-UV measures purity and quantity directly without derivatization, and LC-MS confirms identity. Full GC testing to the monograph is available and quoted.

Is clioquinol sensitive to light?

Yes. It can darken and release iodine on exposure to light, which is why the monograph limits free iodine and iodide. Store and ship samples in opaque containers.

Why can clioquinol give tailing peaks?

Like other 8-hydroxyquinolines it binds metal ions, so trace metals in the system can distort the peak. The method uses conditions that limit metal binding.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/2788

Identity facts from the USP monograph header for this compound.

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