Cyclizine hydrochloride

Cyclizine hydrochloride: antihistamine (piperazine).

Cyclizine hydrochloride testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Cyclizine hydrochloride: 2D structure drawn from the PubChem record (CID 6420019).

Compound data

CAS number

303-25-3

Formula

C₁₈H₂₂N₂ · HCl

Molecular weight

302.84 g/mol

Type

Antihistamine (piperazine)

Structure and names

Identity: Cyclizine hydrochloride

IUPAC name: 1-benzhydryl-4-methylpiperazine;hydrochloride

How Vanguard tests Cyclizine hydrochloride

Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by infrared spectroscopy and a chloride test, assay by nonaqueous titration with perchloric acid, organic impurities by GC with flame ionization, residue on ignition, pH and loss on drying. Full testing to the USP Cyclizine Hydrochloride monograph is available and quoted.

What's reported

Purity, as percent of total peak area
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit
Microbiology (injectables)
Endotoxin	$210
Sterility or bioburden	$150
Container closure integrity (CCI)	$50
Screening
Fentanyl screen	$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Cyclizine Hydrochloride (CAS 303-25-3)
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Cyclizine hydrochloride testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and assay, with LC-MS to confirm identity. Full testing to the USP Cyclizine Hydrochloride monograph is available and quoted.

Is the result reported as the hydrochloride or the free base?

The monograph defines cyclizine hydrochloride, so assay is reported on the salt basis unless you ask for a free base figure.

What related compounds can occur in cyclizine?

Benzhydrol, benzophenone and 1-methylpiperazine can carry through from synthesis or form on degradation. HPLC separates them from cyclizine, and LC-MS confirms identity.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/6420019

Identity facts from the USP monograph header for this compound.

Order

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