Cyclophosphamide: nitrogen mustard alkylating agent.
Cyclophosphamide testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.
Cyclophosphamide: 2D structure drawn from the PubChem record (CID 22420).
6055-19-2
C7H15Cl2N2O2P · H2O
279.10 g/mol
Nitrogen mustard alkylating agent
Identity: Cyclophosphamide (monohydrate)
IUPAC name: N,N-bis(2-chloroethyl)-2-oxo-1,3,2lambda5-oxazaphosphinan-2-amine;hydrate
Method for the $250 identity, purity and quantity test: Chromatographic assay, with detection selected for the compound, against a reference standard, with results in 3 to 5 business days.
The USP monograph covers identity by infrared spectroscopy and HPLC retention time, assay by HPLC with UV at 195 nm, propanolamine and degradation products by thin-layer chromatography, chloride by potentiometric titration, a phosphate limit, pH, water determination, and bacterial endotoxins and sterility where labeled sterile. Full testing to the USP Cyclophosphamide monograph is available and quoted.
Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.
| Add-on test | Price |
|---|---|
| Identity and impurities | |
| FTIR identity | $90 |
| CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur) | $125 |
| Chiral purity (where a chiral method exists; new methods quoted) | $250 |
| Water, solvents and salt form | |
| Water content by Karl Fischer | $60 |
| Residual solvents | $150 |
| Counterions: chloride, acetate and TFA | $70 |
| Assay | |
| Assay, % w/w (with raw powder purity; $250 together) | +$50 |
| Metals and conformity | |
| Heavy metals: arsenic, cadmium, chromium, mercury and lead | $150 |
| Conformity: purity and quantity on more units from the same lot | $100 per extra unit |
| Microbiology (injectables) | |
| Endotoxin | $210 |
| Sterility or bioburden | $150 |
| Container closure integrity (CCI) | $50 |
| Screening | |
| Fentanyl screen | $50 |
10% off for 10 or more samples.
Need something else? Other tests are available on request.
Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.
No. The $250 test covers identity, purity and quantity by a chromatographic assay, with detection selected for the compound. Full testing to the USP Cyclophosphamide monograph is available and quoted.
The USP material is usually the monohydrate. The anhydrous form weighs less per mole, so water content and the labeled form decide the basis for the assay.
It has almost no UV chromophore, so the lab uses a detection method suited to the compound.
Yes. The monohydrate can lose water and melt at fairly low temperatures, and it hydrolyzes in solution. Samples should be kept cool and dry.
https://pubchem.ncbi.nlm.nih.gov/compound/22420
Identity facts from the USP monograph header for this compound.
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