Dacarbazine

Dacarbazine: triazene alkylating agent.

Dacarbazine testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Dacarbazine: 2D structure drawn from the PubChem record (CID 135398738).

Compound data

CAS number

4342-03-4

Formula

C₆H₁₀N₆O

Molecular weight

182.19 g/mol

Type

Triazene alkylating agent

Structure and names

Identity: Dacarbazine

IUPAC name: 4-[(E)-dimethylaminodiazenyl]-1H-imidazole-5-carboxamide

How Vanguard tests Dacarbazine

Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by infrared spectroscopy and HPLC retention time, assay by HPLC with UV at 250 nm, organic impurities by HPLC, and dimethylamine by headspace GC with flame ionization. Full testing to the USP Dacarbazine monograph is available and quoted.

What's reported

Purity, as percent of total peak area
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit
Microbiology (injectables)
Endotoxin	$210
Sterility or bioburden	$150
Container closure integrity (CCI)	$50
Screening
Fentanyl screen	$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Dacarbazine (CAS 4342-03-4)
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Dacarbazine testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and assay, with LC-MS to confirm identity. Full testing to the USP Dacarbazine monograph is available and quoted.

Is dacarbazine sensitive to light?

Yes. Light breaks dacarbazine down to products such as 2-azahypoxanthine and 5-aminoimidazole-4-carboxamide. Ship and store samples in opaque containers.

Why does the monograph test for dimethylamine?

Dimethylamine is released when the triazene group breaks down, so it is a marker of degradation. It is volatile and is measured by headspace GC, which is quoted separately.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/135398738

Identity facts from the USP monograph header for this compound.

Order

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