Demecarium bromide: cholinesterase inhibitor (bis-quaternary carbamate).
Demecarium bromide testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.
Demecarium bromide: 2D structure drawn from the PubChem record (CID 5965).
56-94-0
C32H52Br2N4O4
716.59 g/mol
Cholinesterase inhibitor (bis-quaternary carbamate)
Identity: Demecarium bromide
IUPAC name: trimethyl-[3-[methyl-[10-[methyl-[3-(trimethylazaniumyl)phenoxy]carbonylamino]decyl]carbamoyl]oxyphenyl]azanium dibromide
Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.
The USP monograph covers identity by infrared spectroscopy, a color reaction, a reineckate precipitate melting point and a bromide test, pH, water determination, residue on ignition, a colorimetric m-trimethylammoniophenol bromide limit, and assay by nonaqueous titration with perchloric acid. Full testing to the USP Demecarium Bromide monograph is available and quoted.
Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.
| Add-on test | Price |
|---|---|
| Identity and impurities | |
| FTIR identity | $90 |
| CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur) | $125 |
| Chiral purity (where a chiral method exists; new methods quoted) | $250 |
| Water, solvents and salt form | |
| Water content by Karl Fischer | $60 |
| Residual solvents | $150 |
| Counterions: chloride, acetate and TFA | $70 |
| Assay | |
| Assay, % w/w (with raw powder purity; $250 together) | +$50 |
| Metals and conformity | |
| Heavy metals: arsenic, cadmium, chromium, mercury and lead | $150 |
| Conformity: purity and quantity on more units from the same lot | $100 per extra unit |
| Microbiology (injectables) | |
| Endotoxin | $210 |
| Sterility or bioburden | $150 |
| Container closure integrity (CCI) | $50 |
| Screening | |
| Fentanyl screen | $50 |
10% off for 10 or more samples.
Need something else? Other tests are available on request.
Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.
No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and assay, with LC-MS to confirm identity. Full testing to the USP Demecarium Bromide monograph is available and quoted.
Demecarium is a dication with two quaternary ammonium groups, so LC-MS detects the doubly charged cation without the two bromide ions.
Its carbamate groups can hydrolyze in solution, especially at higher pH, and the breakdown products separate from demecarium in the HPLC purity profile.
https://pubchem.ncbi.nlm.nih.gov/compound/5965
Identity facts from the USP monograph header for this compound.
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