Diphenhydramine hydrochloride: ethanolamine antihistamine.
Diphenhydramine hydrochloride testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.
Diphenhydramine hydrochloride: 2D structure drawn from the PubChem record (CID 8980).
147-24-0
C17H21NO · HCl
291.82 g/mol
Ethanolamine antihistamine
Identity: Diphenhydramine hydrochloride
IUPAC name: 2-benzhydryloxy-N,N-dimethylethanamine;hydrochloride
Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.
The USP Diphenhydramine Citrate monograph covers identity by infrared spectroscopy, HPLC retention time and a citrate test, assay by HPLC, organic impurities by HPLC, plus residue on ignition and loss on drying; the oral powder monograph uses HPLC with UV spectral matching for identity. Full testing to the USP Diphenhydramine Hydrochloride monograph is available and quoted.
Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.
| Add-on test | Price |
|---|---|
| Identity and impurities | |
| FTIR identity | $90 |
| CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur) | $125 |
| Chiral purity (where a chiral method exists; new methods quoted) | $250 |
| Water, solvents and salt form | |
| Water content by Karl Fischer | $60 |
| Residual solvents | $150 |
| Counterions: chloride, acetate and TFA | $70 |
| Assay | |
| Assay, % w/w (with raw powder purity; $250 together) | +$50 |
| Metals and conformity | |
| Heavy metals: arsenic, cadmium, chromium, mercury and lead | $150 |
| Conformity: purity and quantity on more units from the same lot | $100 per extra unit |
| Microbiology (injectables) | |
| Endotoxin | $210 |
| Sterility or bioburden | $150 |
| Container closure integrity (CCI) | $50 |
| Screening | |
| Fentanyl screen | $50 |
10% off for 10 or more samples.
Need something else? Other tests are available on request.
Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.
No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and assay and LC-MS for identity. Full testing to the USP Diphenhydramine Hydrochloride monograph is available and quoted.
They are two salts of the same base. The citrate is much heavier, so a given amount of diphenhydramine base takes more citrate salt by weight. Tell us which salt the label claim refers to.
Yes. Diphenhydramine is often combined with pain relievers or decongestants, and HPLC separates it from those actives so each can be reported against its label claim.
https://pubchem.ncbi.nlm.nih.gov/compound/8980
Identity facts from the USP monograph header for this compound.
Start an order online, or send the compound name and the tests you need for a quote.
