Docetaxel

Docetaxel: taxane (microtubule stabilizer).

Docetaxel testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Docetaxel: 2D structure drawn from the PubChem record (CID 148124).

Compound data

CAS number

114977-28-5

Formula

C₄₃H₅₃NO₁₄

Molecular weight

807.88 g/mol

Type

Taxane (microtubule stabilizer)

Structure and names

Identity: Docetaxel (anhydrous)

IUPAC name: [(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-acetyloxy-1,9,12-trihydroxy-15-[(2R,3S)-2-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]oxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate

How Vanguard tests Docetaxel

Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by infrared spectroscopy and HPLC retention time, assay by HPLC, organic impurities by two HPLC procedures, residue on ignition, optical rotation, water content, microbial enumeration, and bacterial endotoxins. Full testing to the USP Docetaxel monograph is available and quoted.

What's reported

Purity, as percent of total peak area
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit
Microbiology (injectables)
Endotoxin	$210
Sterility or bioburden	$150
Container closure integrity (CCI)	$50
Screening
Fentanyl screen	$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Docetaxel (CAS 114977-28-5; trihydrate CAS 148408-66-6)
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Docetaxel testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and quantity and LC-MS for identity. Full testing to the USP Docetaxel monograph is available and quoted.

Is docetaxel tested as the anhydrous form or the trihydrate?

Docetaxel is supplied both as anhydrous material and as the trihydrate. The USP assay is calculated on the anhydrous basis, so water content is needed to compare a result to label.

Can the test detect 7-epidocetaxel?

Yes. 7-Epidocetaxel is a common degradation product with the same mass as docetaxel. It is separated from docetaxel by HPLC and reported in the purity profile.

Can the test tell docetaxel from paclitaxel?

Yes. The two taxanes differ in side-chain structure, retention time and mass by LC-MS.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/148124

Identity facts from the USP monograph header for this compound.

Order

Start an order online, or send the compound name and the tests you need for a quote.

All research compounds