Doxorubicin hydrochloride: anthracycline.
Doxorubicin hydrochloride testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.
Doxorubicin hydrochloride: 2D structure drawn from the PubChem record (CID 443939).
25316-40-9
C27H29NO11 · HCl
579.98 g/mol
Anthracycline
Identity: Doxorubicin hydrochloride
IUPAC name: (7S,9S)-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride
Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.
The USP monograph covers identity by HPLC retention time, infrared spectroscopy and a chloride test, assay by HPLC, related compounds by HPLC, residual acetone and alcohol by GC, pH, and water content. Full testing to the USP Doxorubicin Hydrochloride monograph is available and quoted.
Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.
| Add-on test | Price |
|---|---|
| Identity and impurities | |
| FTIR identity | $90 |
| CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur) | $125 |
| Chiral purity (where a chiral method exists; new methods quoted) | $250 |
| Water, solvents and salt form | |
| Water content by Karl Fischer | $60 |
| Residual solvents | $150 |
| Counterions: chloride, acetate and TFA | $70 |
| Assay | |
| Assay, % w/w (with raw powder purity; $250 together) | +$50 |
| Metals and conformity | |
| Heavy metals: arsenic, cadmium, chromium, mercury and lead | $150 |
| Conformity: purity and quantity on more units from the same lot | $100 per extra unit |
| Microbiology (injectables) | |
| Endotoxin | $210 |
| Sterility or bioburden | $150 |
| Container closure integrity (CCI) | $50 |
| Screening | |
| Fentanyl screen | $50 |
10% off for 10 or more samples.
Need something else? Other tests are available on request.
Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.
No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and quantity and LC-MS for identity. Full testing to the USP Doxorubicin Hydrochloride monograph is available and quoted.
Daunorubicin differs in mass and retention time and is a known related compound. Epirubicin is a stereoisomer with the same mass, so it is distinguished by HPLC retention time rather than by LC-MS.
Yes. Doxorubicin degrades under light and in basic solution, and the aglycone doxorubicinone is a common degradation product. Samples should be kept dark and cool.
Doxorubicin can adsorb to glass and some plastics at low concentrations, so dilute solutions are prepared in suitable containers and analyzed promptly.
https://pubchem.ncbi.nlm.nih.gov/compound/443939
Identity facts from the USP monograph header for this compound.
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