Hydroxychloroquine sulfate

Hydroxychloroquine sulfate: 4-Aminoquinoline antimalarial.

Hydroxychloroquine sulfate testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Hydroxychloroquine sulfate: 2D structure drawn from the PubChem record (CID 12947).

Compound data

CAS number

747-36-4

Formula

C₁₈H₂₆ClN₃O · H₂SO₄

Molecular weight

433.95 g/mol

Type

4-Aminoquinoline antimalarial

Structure and names

Identity: Hydroxychloroquine sulfate

IUPAC name: 2-[4-[(7-chloroquinolin-4-yl)amino]pentyl-ethylamino]ethanol;sulfuric acid

How Vanguard tests Hydroxychloroquine sulfate

Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by HPLC retention time, infrared spectroscopy and a sulfate test, assay by HPLC, organic impurities by HPLC, plus loss on drying. Full testing to the USP Hydroxychloroquine Sulfate monograph is available and quoted.

What's reported

Purity, as percent of total peak area
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit
Microbiology (injectables)
Endotoxin	$210
Sterility or bioburden	$150
Container closure integrity (CCI)	$50
Screening
Fentanyl screen	$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Hydroxychloroquine Sulfate (CAS 747-36-4)
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Hydroxychloroquine sulfate testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and assay and LC-MS for identity. Full testing to the USP Hydroxychloroquine Sulfate monograph is available and quoted.

Can the test tell hydroxychloroquine from chloroquine?

Yes. Hydroxychloroquine has one extra hydroxyl group, so it is 16 mass units heavier by LC-MS and elutes at a different HPLC retention time.

Is the result reported as the sulfate or the base?

The monograph assays hydroxychloroquine sulfate, and tablet label claims are usually stated as the sulfate too. A base figure can be calculated if you need one.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/12947

Identity facts from the USP monograph header for this compound.

Order

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