Ibuprofen

Ibuprofen: nSAID (propionic acid derivative).

Ibuprofen testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Ibuprofen: 2D structure drawn from the PubChem record (CID 3672).

Compound data

CAS number

15687-27-1

Formula

C₁₃H₁₈O₂

Molecular weight

206.28 g/mol

Type

NSAID (propionic acid derivative)

Structure and names

Identity: Ibuprofen

IUPAC name: 2-[4-(2-methylpropyl)phenyl]propanoic acid

How Vanguard tests Ibuprofen

Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by infrared spectroscopy, UV spectroscopy and HPLC retention time, assay by HPLC, organic impurities by HPLC, and water and residue on ignition. Full testing to the USP Ibuprofen monograph is available and quoted.

What's reported

Purity, as percent of total peak area
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit
Microbiology (injectables)
Endotoxin	$210
Sterility or bioburden	$150
Container closure integrity (CCI)	$50
Screening
Fentanyl screen	$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Ibuprofen (CAS 15687-27-1)
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Ibuprofen testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and assay, with LC-MS to confirm identity. Full testing to the USP Ibuprofen monograph is available and quoted.

Is ibuprofen a racemic mixture?

Yes. Standard ibuprofen is a racemic mixture of the R and S enantiomers, while dexibuprofen is the single S form. A standard HPLC purity test does not separate the two, and chiral testing is quoted separately.

What impurity is commonly checked in ibuprofen?

4-Isobutylacetophenone is a known ibuprofen impurity from synthesis and degradation, and it appears as a separate peak in the HPLC purity profile.

What forms does ibuprofen arrive in?

Usually white crystalline powder, tablets, softgel capsules or oral suspensions. Softgels and suspensions need a different extraction from tablets, so tell us the form when you submit.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/3672

Identity facts from the USP monograph header for this compound.

Order

Start an order online, or send the compound name and the tests you need for a quote.

All research compounds