L-proline

L-proline: amino acid.

L-proline testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

L-proline: 2D structure drawn from the PubChem record (CID 145742).

Compound data

CAS number

147-85-3

Formula

C₅H₉NO₂

Molecular weight

115.13 g/mol

Type

Amino acid

Structure and names

Identity: L-proline

IUPAC name: (2S)-pyrrolidine-2-carboxylic acid

How Vanguard tests L-proline

Method for the $250 identity, purity and quantity test: Chromatographic assay, with detection selected for the compound, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by infrared spectroscopy, assay by titration, related compounds by TLC, chloride, sulfate and iron limit tests, residue on ignition, optical rotation, and loss on drying. Full testing to the USP Proline monograph is available and quoted.

What's reported

Purity, as percent of total peak area
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Proline (CAS 147-85-3)
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about L-proline testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by a chromatographic assay, with detection selected for the compound. Full testing to the USP Proline monograph is available and quoted.

Can the test tell proline from hydroxyproline?

Yes. Hydroxyproline, common in collagen products, has one extra oxygen, so it differs in mass and retention time.

Can the test tell L-proline from D-proline?

Not by the standard test, since the two forms have the same mass and retention time. Optical rotation or a chiral method is needed.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/145742

Identity facts from the USP monograph header for this compound.

Order

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