Leflunomide: immunomodulator (isoxazole DHODH inhibitor prodrug).
Leflunomide testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.
Leflunomide: 2D structure drawn from the PubChem record (CID 3899).
75706-12-6
C12H9F3N2O2
270.21 g/mol
Immunomodulator (isoxazole DHODH inhibitor prodrug)
Identity: Leflunomide
IUPAC name: 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.
The USP monograph covers identity by infrared spectroscopy and HPLC retention time, assay by HPLC, organic impurities by HPLC, residue on ignition, melting range, and loss on drying. Full testing to the USP Leflunomide monograph is available and quoted.
Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.
| Add-on test | Price |
|---|---|
| Identity and impurities | |
| FTIR identity | $90 |
| CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur) | $125 |
| Chiral purity (where a chiral method exists; new methods quoted) | $250 |
| Water, solvents and salt form | |
| Water content by Karl Fischer | $60 |
| Residual solvents | $150 |
| Counterions: chloride, acetate and TFA | $70 |
| Assay | |
| Assay, % w/w (with raw powder purity; $250 together) | +$50 |
| Metals and conformity | |
| Heavy metals: arsenic, cadmium, chromium, mercury and lead | $150 |
| Conformity: purity and quantity on more units from the same lot | $100 per extra unit |
| Microbiology (injectables) | |
| Endotoxin | $210 |
| Sterility or bioburden | $150 |
| Container closure integrity (CCI) | $50 |
| Screening | |
| Fentanyl screen | $50 |
10% off for 10 or more samples.
Need something else? Other tests are available on request.
Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.
No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and quantity and LC-MS for identity. Full testing to the USP Leflunomide monograph is available and quoted.
Yes. The isoxazole ring opens to teriflunomide, which has the same molecular formula. The two are told apart by HPLC retention time rather than by mass, so a sample labelled as one can be checked for the other.
It is a starting material and breakdown product that is controlled as a related compound. It separates from leflunomide in the HPLC purity profile.
https://pubchem.ncbi.nlm.nih.gov/compound/3899
Identity facts from the USP monograph header for this compound.
Start an order online, or send the compound name and the tests you need for a quote.
