Levofloxacin: fluoroquinolone antibiotic.
Levofloxacin testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.
Levofloxacin: 2D structure drawn from the PubChem record (CID 3033924).
138199-71-0
C18H20FN3O4 · 1/2H2O
370.38 g/mol
Fluoroquinolone antibiotic
Identity: Levofloxacin hemihydrate
IUPAC name: bis((2S)-7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid);hydrate
Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.
The USP monograph covers identity by infrared spectroscopy and HPLC retention time, assay by HPLC, organic impurities and enantiomeric purity by HPLC, residue on ignition, optical rotation, and water content. Full testing to the USP Levofloxacin monograph is available and quoted.
Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.
| Add-on test | Price |
|---|---|
| Identity and impurities | |
| FTIR identity | $90 |
| CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur) | $125 |
| Chiral purity (where a chiral method exists; new methods quoted) | $250 |
| Water, solvents and salt form | |
| Water content by Karl Fischer | $60 |
| Residual solvents | $150 |
| Counterions: chloride, acetate and TFA | $70 |
| Assay | |
| Assay, % w/w (with raw powder purity; $250 together) | +$50 |
| Metals and conformity | |
| Heavy metals: arsenic, cadmium, chromium, mercury and lead | $150 |
| Conformity: purity and quantity on more units from the same lot | $100 per extra unit |
| Microbiology (injectables) | |
| Endotoxin | $210 |
| Sterility or bioburden | $150 |
| Container closure integrity (CCI) | $50 |
| Screening | |
| Fentanyl screen | $50 |
10% off for 10 or more samples.
Need something else? Other tests are available on request.
Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.
No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and quantity and LC-MS for identity. Full testing to the USP Levofloxacin monograph is available and quoted.
Levofloxacin is the single S-enantiomer of ofloxacin, which is a racemic mix of both forms. They have the same mass and the same retention time on a standard column, so telling them apart needs a chiral HPLC method, which is quoted separately.
Levofloxacin is usually supplied as the hemihydrate. Results are calculated on the anhydrous basis, so water content is part of comparing the result to a label claim.
https://pubchem.ncbi.nlm.nih.gov/compound/3033924
Identity facts from the USP monograph header for this compound.
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