Milbemycin oxime: macrocyclic lactone anthelmintic (veterinary).
Milbemycin oxime testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.
Milbemycin oxime: 2D structure drawn from the PubChem record (CID 20056431).
129496-10-2
C31H43NO7 (A3 oxime); C32H45NO7 (A4 oxime)
541.69 (A3 oxime); 555.71 (A4 oxime) g/mol
Macrocyclic lactone anthelmintic (veterinary)
Identity: Milbemycin oxime (A3 and A4 oxime mixture)
IUPAC name: (1R,4S,5’S,6R,6’R,8R,10E,13R,14E,16E,20R,21Z,24S)-6′-ethyl-24-hydroxy-21-hydroxyimino-5′,11,13,22-tetramethylspiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2′-oxane]-2-one;(1R,4S,5’S,6R,6’R,8R,10E,13R,14E,16E,20R,21Z,24S)-24-hydroxy-21-hydroxyimino-5′,6′,11,13,22-pentamethylspiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2′-oxane]-2-one
Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.
The USP monograph covers identity by infrared spectroscopy and HPLC retention time, assay by HPLC, organic impurities by HPLC, residue on ignition, and water content. Full testing to the USP Milbemycin Oxime monograph is available and quoted.
Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.
| Add-on test | Price |
|---|---|
| Identity and impurities | |
| FTIR identity | $90 |
| CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur) | $125 |
| Chiral purity (where a chiral method exists; new methods quoted) | $250 |
| Water, solvents and salt form | |
| Water content by Karl Fischer | $60 |
| Residual solvents | $150 |
| Counterions: chloride, acetate and TFA | $70 |
| Assay | |
| Assay, % w/w (with raw powder purity; $250 together) | +$50 |
| Metals and conformity | |
| Heavy metals: arsenic, cadmium, chromium, mercury and lead | $150 |
| Conformity: purity and quantity on more units from the same lot | $100 per extra unit |
| Microbiology (injectables) | |
| Endotoxin | $210 |
| Sterility or bioburden | $150 |
| Container closure integrity (CCI) | $50 |
| Screening | |
| Fentanyl screen | $50 |
10% off for 10 or more samples.
Need something else? Other tests are available on request.
Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.
No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and quantity and LC-MS for identity. Full testing to the USP Milbemycin Oxime monograph is available and quoted.
Milbemycin oxime is a mixture of milbemycin A3 oxime and milbemycin A4 oxime, which differ by one carbon. HPLC separates the two and LC-MS confirms each by mass, so the result can report both components and their ratio.
Macrocyclic lactones of this type can degrade with light, heat and strong acid or base, which adds peaks to the purity profile. Samples should be kept cool and protected from light before testing.
Yes. The drug is extracted from the tablet and quantified against a reference standard. Flavored chewables can need extra cleanup so the matrix does not interfere with the HPLC peaks.
https://pubchem.ncbi.nlm.nih.gov/compound/20056431
Identity facts from the USP monograph header for this compound.
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