Mycophenolate: immunosuppressant (IMPDH inhibitor).
Mycophenolate testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.
Mycophenolate: 2D structure drawn from the PubChem record (CID 446541).
24280-93-1
C17H20O6
320.34 g/mol
Immunosuppressant (IMPDH inhibitor)
Identity: Mycophenolic acid
IUPAC name: (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methylhex-4-enoic acid
Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.
The USP monographs cover identity by infrared spectroscopy, UV spectrum and HPLC retention time, assay by HPLC, and related compounds by HPLC. Full testing to the USP Mycophenolate Mofetil, Mycophenolate Sodium or Mycophenolic Acid monograph is available and quoted.
Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.
| Add-on test | Price |
|---|---|
| Identity and impurities | |
| FTIR identity | $90 |
| CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur) | $125 |
| Chiral purity (where a chiral method exists; new methods quoted) | $250 |
| Water, solvents and salt form | |
| Water content by Karl Fischer | $60 |
| Residual solvents | $150 |
| Counterions: chloride, acetate and TFA | $70 |
| Assay | |
| Assay, % w/w (with raw powder purity; $250 together) | +$50 |
| Metals and conformity | |
| Heavy metals: arsenic, cadmium, chromium, mercury and lead | $150 |
| Conformity: purity and quantity on more units from the same lot | $100 per extra unit |
| Microbiology (injectables) | |
| Endotoxin | $210 |
| Sterility or bioburden | $150 |
| Container closure integrity (CCI) | $50 |
| Screening | |
| Fentanyl screen | $50 |
10% off for 10 or more samples.
Need something else? Other tests are available on request.
Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.
No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and quantity and LC-MS for identity. Full testing to the USP Mycophenolate Mofetil, Mycophenolate Sodium or Mycophenolic Acid monograph is available and quoted.
Yes. Mycophenolate mofetil is the morpholinoethyl ester of mycophenolic acid, so the two differ in HPLC retention time and mass by LC-MS. Free mycophenolic acid in mofetil material shows up as a related compound.
The sample is tested and reported as the form named on the label, mofetil, sodium salt or acid. Converting between them changes the number, so the basis is stated on the report.
Yes. The ester hydrolyzes to mycophenolic acid in solution, faster at basic pH, so samples are prepared just before analysis.
https://pubchem.ncbi.nlm.nih.gov/compound/446541
Identity facts from the USP monograph header for this compound.
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