Naloxone hydrochloride: opioid antagonist.
Naloxone hydrochloride testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.
Naloxone hydrochloride: 2D structure drawn from the PubChem record (CID 5464092).
357-08-4
C19H21NO4 · HCl
363.84 g/mol
Opioid antagonist
Identity: Naloxone hydrochloride (anhydrous)
IUPAC name: (4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one;hydrochloride
Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.
The USP Naloxone Hydrochloride monograph covers identity by infrared spectroscopy and HPLC retention time, assay by HPLC, related compounds by HPLC, chloride content by titration, optical rotation and loss on drying. Full testing to the USP Naloxone Hydrochloride monograph is available and quoted.
Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.
| Add-on test | Price |
|---|---|
| Identity and impurities | |
| FTIR identity | $90 |
| CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur) | $125 |
| Chiral purity (where a chiral method exists; new methods quoted) | $250 |
| Water, solvents and salt form | |
| Water content by Karl Fischer | $60 |
| Residual solvents | $150 |
| Counterions: chloride, acetate and TFA | $70 |
| Assay | |
| Assay, % w/w (with raw powder purity; $250 together) | +$50 |
| Metals and conformity | |
| Heavy metals: arsenic, cadmium, chromium, mercury and lead | $150 |
| Conformity: purity and quantity on more units from the same lot | $100 per extra unit |
| Microbiology (injectables) | |
| Endotoxin | $210 |
| Sterility or bioburden | $150 |
| Container closure integrity (CCI) | $50 |
| Screening | |
| Fentanyl screen | $50 |
10% off for 10 or more samples.
Need something else? Other tests are available on request.
Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.
No. The $250 test covers identity, purity and quantity by HPLC with UV detection for purity and assay, and LC-MS for identity. Full testing to the USP Naloxone Hydrochloride monograph is available and quoted.
Yes. The three forms have different molecular weights, so a result reported as naloxone hydrochloride reads differently from one reported as free base. Tell us which form is on the label so the assay is calculated on the right basis.
Yes. Naloxone and naltrexone differ in mass and retention time, so the LC-MS identity check and the HPLC purity profile separate them.
Most samples are a white to off-white powder or a solution. For solutions, send the stated concentration so the quantity result can be compared against it.
https://pubchem.ncbi.nlm.nih.gov/compound/5464092
Identity facts from the USP monograph header for this compound.
Start an order online, or send the compound name and the tests you need for a quote.
