Naltrexone hydrochloride: opioid receptor antagonist.
Naltrexone hydrochloride testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.
Naltrexone hydrochloride: 2D structure drawn from the PubChem record (CID 5360515).
16590-41-3
C20H23NO4
341.41 g/mol
Opioid receptor antagonist
Identity: Naltrexone (free base)
IUPAC name: (4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.
The USP monograph covers identity by infrared spectroscopy and HPLC retention time, assay by HPLC, organic impurities by HPLC, residue on ignition, total solvents, chloride by titration, optical rotation, water and solution clarity. Full testing to the USP Naltrexone Hydrochloride monograph is available and quoted.
Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.
| Add-on test | Price |
|---|---|
| Identity and impurities | |
| FTIR identity | $90 |
| CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur) | $125 |
| Chiral purity (where a chiral method exists; new methods quoted) | $250 |
| Water, solvents and salt form | |
| Water content by Karl Fischer | $60 |
| Residual solvents | $150 |
| Counterions: chloride, acetate and TFA | $70 |
| Assay | |
| Assay, % w/w (with raw powder purity; $250 together) | +$50 |
| Metals and conformity | |
| Heavy metals: arsenic, cadmium, chromium, mercury and lead | $150 |
| Conformity: purity and quantity on more units from the same lot | $100 per extra unit |
| Microbiology (injectables) | |
| Endotoxin | $210 |
| Sterility or bioburden | $150 |
| Container closure integrity (CCI) | $50 |
| Screening | |
| Fentanyl screen | $50 |
10% off for 10 or more samples.
Need something else? Other tests are available on request.
Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.
No. The $250 test covers identity, purity and quantity by HPLC with UV detection for purity and assay, and LC-MS for identity. Full testing to the USP Naltrexone Hydrochloride monograph is available and quoted.
Naltrexone is supplied as the hydrochloride salt, sometimes as a dihydrate. Results can be reported as the salt or the free base, so tell us which basis your label uses.
They are close structural relatives, but naltrexone has a cyclopropylmethyl group where naloxone has an allyl group. The masses and HPLC retention times differ, so LC-MS and HPLC tell them apart.
Yes. Capsules and tablets are extracted and assayed by HPLC against the label claim. Let us know the strength per unit when you send them.
https://pubchem.ncbi.nlm.nih.gov/compound/5360515
Identity facts from the USP monograph header for this compound.
Start an order online, or send the compound name and the tests you need for a quote.
