Octocrylene

Octocrylene: sunscreen UV filter (cyanoacrylate ester).

Octocrylene testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Octocrylene: 2D structure drawn from the PubChem record (CID 22571).

Compound data

CAS number

6197-30-4

Formula

C₂₄H₂₇NO₂

Molecular weight

361.48 g/mol

Type

Sunscreen UV filter (cyanoacrylate ester)

Structure and names

Identity: Octocrylene

IUPAC name: 2-ethylhexyl 2-cyano-3,3-diphenylprop-2-enoate

How Vanguard tests Octocrylene

Method for the $250 identity, purity and quantity test: GC-FID assay and purity, GC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by UV spectroscopy and GC retention time, assay by GC, organic impurities by GC, specific gravity, refractive index and acidity by titration. Full testing to the USP Octocrylene monograph is available and quoted.

What's reported

Purity, as percent of total peak area
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit
Microbiology (injectables)
Endotoxin	$210
Sterility or bioburden	$150
Container closure integrity (CCI)	$50
Screening
Fentanyl screen	$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Octocrylene (CAS 6197-30-4)
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Octocrylene testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by GC-FID for assay and purity, and GC-MS for identity. Full testing to the USP Octocrylene monograph is available and quoted.

Why is octocrylene tested by GC?

Octocrylene is a viscous oily ester and the USP measures it and its impurities by GC. GC-MS adds identity from the mass spectrum.

What degradation products are linked to octocrylene?

Octocrylene can break down over time to benzophenone, which can be checked by GC-MS. Older stock or product stored warm is worth checking for it.

Can octocrylene be measured in a finished sunscreen?

Yes, after extraction from the product. Let us know the other UV filters in the formula so the method separates them.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/22571

Identity facts from the USP monograph header for this compound.

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