Omeprazole: proton pump inhibitor (benzimidazole).
Omeprazole testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.
Omeprazole: 2D structure drawn from the PubChem record (CID 4594).
73590-58-6
C17H19N3O3S
345.42 g/mol
Proton pump inhibitor (benzimidazole)
Identity: Omeprazole
IUPAC name: 6-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methylsulfinyl]-1H-benzimidazole
Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.
The USP monograph covers identity by infrared spectroscopy and HPLC retention time, assay by HPLC, organic impurities by HPLC, a visible absorbance limit for two related compounds, plus residue on ignition, completeness of solution and loss on drying. Full testing to the USP Omeprazole monograph is available and quoted.
Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.
| Add-on test | Price |
|---|---|
| Identity and impurities | |
| FTIR identity | $90 |
| CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur) | $125 |
| Chiral purity (where a chiral method exists; new methods quoted) | $250 |
| Water, solvents and salt form | |
| Water content by Karl Fischer | $60 |
| Residual solvents | $150 |
| Counterions: chloride, acetate and TFA | $70 |
| Assay | |
| Assay, % w/w (with raw powder purity; $250 together) | +$50 |
| Metals and conformity | |
| Heavy metals: arsenic, cadmium, chromium, mercury and lead | $150 |
| Conformity: purity and quantity on more units from the same lot | $100 per extra unit |
| Microbiology (injectables) | |
| Endotoxin | $210 |
| Sterility or bioburden | $150 |
| Container closure integrity (CCI) | $50 |
| Screening | |
| Fentanyl screen | $50 |
10% off for 10 or more samples.
Need something else? Other tests are available on request.
Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.
No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and assay and LC-MS for identity. Full testing to the USP Omeprazole monograph is available and quoted.
Omeprazole breaks down quickly in acid and slowly with heat, light and moisture, and its breakdown products are colored. Discolored powder or pellets usually show lower assay and extra impurity peaks.
Not with the standard method. Esomeprazole is the S-enantiomer of omeprazole, with the same mass and retention time, so a chiral HPLC method is needed, which is quoted separately.
Yes. The enteric-coated pellets are extracted in a basic solution to protect the omeprazole, and the result is reported as percent of the label claim.
https://pubchem.ncbi.nlm.nih.gov/compound/4594
Identity facts from the USP monograph header for this compound.
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