Paroxetine hydrochloride: selective serotonin reuptake inhibitor (SSRI).
Paroxetine hydrochloride testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.
Paroxetine hydrochloride: 2D structure drawn from the PubChem record (CID 5282487).
110429-35-1
C19H20FNO3 · HCl · ½H2O
374.83 g/mol
Selective serotonin reuptake inhibitor (SSRI)
Identity: Paroxetine hydrochloride hemihydrate
IUPAC name: bis((3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine);hydrate;dihydrochloride
Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.
The USP monograph covers identity by infrared spectroscopy, a chloride test and HPLC retention time, assay by HPLC, related compounds and organic impurities by HPLC, plus residue on ignition and water content. Full testing to the USP Paroxetine Hydrochloride monograph is available and quoted.
Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.
| Add-on test | Price |
|---|---|
| Identity and impurities | |
| FTIR identity | $90 |
| CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur) | $125 |
| Chiral purity (where a chiral method exists; new methods quoted) | $250 |
| Water, solvents and salt form | |
| Water content by Karl Fischer | $60 |
| Residual solvents | $150 |
| Counterions: chloride, acetate and TFA | $70 |
| Assay | |
| Assay, % w/w (with raw powder purity; $250 together) | +$50 |
| Metals and conformity | |
| Heavy metals: arsenic, cadmium, chromium, mercury and lead | $150 |
| Conformity: purity and quantity on more units from the same lot | $100 per extra unit |
| Microbiology (injectables) | |
| Endotoxin | $210 |
| Sterility or bioburden | $150 |
| Container closure integrity (CCI) | $50 |
| Screening | |
| Fentanyl screen | $50 |
10% off for 10 or more samples.
Need something else? Other tests are available on request.
Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.
No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and assay and LC-MS for identity. Full testing to the USP Paroxetine Hydrochloride monograph is available and quoted.
Yes, for the assay. The hemihydrate carries about half a mole of water per mole, so its theoretical paroxetine content is lower than the anhydrous salt; tell us which form you have so the result is calculated on the right basis.
No. Both forms give the same paroxetine ion in LC-MS. Water content, which the monograph measures separately, is what distinguishes them.
Powder, tablets and oral suspension. Tablets are ground and extracted, and the result can be reported as percent of label claim.
https://pubchem.ncbi.nlm.nih.gov/compound/5282487
Identity facts from the USP monograph header for this compound.
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