Pyrantel pamoate

Pyrantel pamoate: tetrahydropyrimidine anthelmintic.

Pyrantel pamoate testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

2D structure of Pyrantel pamoate

Pyrantel pamoate: 2D structure drawn from the PubChem record (CID 5281033).

Compound data

CAS number

22204-24-6

Formula

C11H14N2S · C23H16O6

Molecular weight

594.68 g/mol

Type

Tetrahydropyrimidine anthelmintic

Structure and names

Identity: Pyrantel pamoate

IUPAC name: 4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid;1-methyl-2-[(E)-2-thiophen-2-ylethenyl]-5,6-dihydro-4H-pyrimidine

How Vanguard tests Pyrantel pamoate

Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by infrared spectroscopy and HPLC retention time, assay by HPLC, organic impurities by HPLC, plus residue on ignition, an iron limit test and loss on drying. Full testing to the USP Pyrantel Pamoate monograph is available and quoted.

What's reported

  • Purity, as percent of total peak area
  • Quantity, against the label claim
  • Identity, reported as match or no match against the reference standard
  • With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on testPrice
Identity and impurities
FTIR identity$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)$125
Chiral purity (where a chiral method exists; new methods quoted)$250
Water, solvents and salt form
Water content by Karl Fischer$60
Residual solvents$150
Counterions: chloride, acetate and TFA$70
Assay
Assay, % w/w (with raw powder purity; $250 together)+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead$150
Conformity: purity and quantity on more units from the same lot$100 per extra unit
Microbiology (injectables)
Endotoxin$210
Sterility or bioburden$150
Container closure integrity (CCI)$50
Screening
Fentanyl screen$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

  • Pyrantel Pamoate (CAS 22204-24-6)
  • Pyrantel Tartrate
  • Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Pyrantel pamoate testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and assay and LC-MS for identity. Full testing to the USP Pyrantel Pamoate monograph is available and quoted.

Why is the pamoate so much heavier than pyrantel itself?

Pamoic acid is a large counter-ion, so pyrantel base is only about a third of the pamoate salt by weight. Label claims are usually stated as pyrantel base, so the result is converted with the molecular weights.

Is pyrantel sensitive to light?

Yes. Pyrantel can isomerize from its trans form to the cis form in light, and the cis isomer shows as a separate HPLC peak. Keep suspensions and pastes protected from light.

What sample forms are usually tested?

Oral suspensions, chewable tablets and veterinary pastes or feed products. Each is extracted and assayed against a pyrantel pamoate reference standard.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/5281033

Identity facts from the USP monograph header for this compound.

Order

Start an order online, or send the compound name and the tests you need for a quote.