Salicylic acid

Salicylic acid: beta hydroxy acid (keratolytic).

Salicylic acid testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

2D structure of Salicylic acid

Salicylic acid: 2D structure drawn from the PubChem record (CID 338).

Compound data

CAS number

69-72-7

Formula

C7H6O3

Molecular weight

138.12 g/mol

Type

Beta hydroxy acid (keratolytic)

Structure and names

Identity: Salicylic acid

IUPAC name: 2-hydroxybenzoic acid

How Vanguard tests Salicylic acid

Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by infrared spectroscopy and HPLC retention time, assay by HPLC, organic impurities by HPLC, residue on ignition, chloride, sulfate and loss on drying. Full testing to the USP Salicylic Acid monograph is available and quoted.

What's reported

  • Purity, as percent of total peak area
  • Quantity, against the label claim
  • Identity, reported as match or no match against the reference standard
  • With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on testPrice
Identity and impurities
FTIR identity$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)$125
Chiral purity (where a chiral method exists; new methods quoted)$250
Water, solvents and salt form
Water content by Karl Fischer$60
Residual solvents$150
Counterions: chloride, acetate and TFA$70
Assay
Assay, % w/w (with raw powder purity; $250 together)+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead$150
Conformity: purity and quantity on more units from the same lot$100 per extra unit
Microbiology (injectables)
Endotoxin$210
Sterility or bioburden$150
Container closure integrity (CCI)$50
Screening
Fentanyl screen$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

  • Salicylic Acid (CAS 69-72-7)
  • Salicylic Acid Plaster
  • Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Salicylic acid testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC with UV detection for purity and assay, and LC-MS for identity. Full testing to the USP Salicylic Acid monograph is available and quoted.

What impurities does salicylic acid have?

The monograph names 4-hydroxybenzoic acid, 4-hydroxyisophthalic acid and phenol, which come from the manufacturing process. HPLC separates and reports each one.

Is salicylic acid the same as acetylsalicylic acid?

No. Acetylsalicylic acid (aspirin) breaks down to salicylic acid, but they are different compounds with different masses and HPLC retention times.

What forms can be tested?

Powder, and finished products such as gels, pads, cleansers and plasters. Finished products need extraction, so tell us the matrix.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/338

Identity facts from the USP monograph header for this compound.

Order

Start an order online, or send the compound name and the tests you need for a quote.