Tizanidine hydrochloride: alpha-2 adrenergic agonist muscle relaxant.
Tizanidine hydrochloride testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.
Tizanidine hydrochloride: 2D structure drawn from the PubChem record (CID 114869).
64461-82-1
C9H8ClN5S · HCl
290.17 g/mol
Alpha-2 adrenergic agonist muscle relaxant
Identity: Tizanidine hydrochloride
IUPAC name: 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine;hydrochloride
Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.
The USP monograph covers identity by infrared spectroscopy, HPLC retention time and a chloride test, assay by HPLC, organic impurities by HPLC, plus residue on ignition, pH and loss on drying. Full testing to the USP Tizanidine Hydrochloride monograph is available and quoted.
Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.
| Add-on test | Price |
|---|---|
| Identity and impurities | |
| FTIR identity | $90 |
| CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur) | $125 |
| Chiral purity (where a chiral method exists; new methods quoted) | $250 |
| Water, solvents and salt form | |
| Water content by Karl Fischer | $60 |
| Residual solvents | $150 |
| Counterions: chloride, acetate and TFA | $70 |
| Assay | |
| Assay, % w/w (with raw powder purity; $250 together) | +$50 |
| Metals and conformity | |
| Heavy metals: arsenic, cadmium, chromium, mercury and lead | $150 |
| Conformity: purity and quantity on more units from the same lot | $100 per extra unit |
| Microbiology (injectables) | |
| Endotoxin | $210 |
| Sterility or bioburden | $150 |
| Container closure integrity (CCI) | $50 |
| Screening | |
| Fentanyl screen | $50 |
10% off for 10 or more samples.
Need something else? Other tests are available on request.
Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.
No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and assay and LC-MS for identity. Full testing to the USP Tizanidine Hydrochloride monograph is available and quoted.
Tablet and capsule label claims are usually stated as tizanidine base, while the drug substance is the hydrochloride. Results can be reported either way using the molecular weights of the two forms.
Yes. Tablets are ground and capsule contents emptied, then both are extracted and assayed against a tizanidine hydrochloride reference standard.
https://pubchem.ncbi.nlm.nih.gov/compound/114869
Identity facts from the USP monograph header for this compound.
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