Valacyclovir hydrochloride: antiviral nucleoside analog prodrug.
Valacyclovir hydrochloride testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.
Valacyclovir hydrochloride: 2D structure drawn from the PubChem record (CID 135398741).
124832-27-5
C13H20N6O4 · HCl
360.80 g/mol
Antiviral nucleoside analog prodrug
Identity: Valacyclovir hydrochloride
IUPAC name: 2-[(2-amino-6-oxo-1H-purin-9-yl)methoxy]ethyl (2S)-2-amino-3-methylbutanoate;hydrochloride
Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.
The USP monograph covers identity by infrared spectroscopy, HPLC retention time and a chloride test, assay by HPLC, impurities by thin-layer chromatography and HPLC, residue on ignition, and water content. Full testing to the USP Valacyclovir Hydrochloride monograph is available and quoted.
Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.
| Add-on test | Price |
|---|---|
| Identity and impurities | |
| FTIR identity | $90 |
| CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur) | $125 |
| Chiral purity (where a chiral method exists; new methods quoted) | $250 |
| Water, solvents and salt form | |
| Water content by Karl Fischer | $60 |
| Residual solvents | $150 |
| Counterions: chloride, acetate and TFA | $70 |
| Assay | |
| Assay, % w/w (with raw powder purity; $250 together) | +$50 |
| Metals and conformity | |
| Heavy metals: arsenic, cadmium, chromium, mercury and lead | $150 |
| Conformity: purity and quantity on more units from the same lot | $100 per extra unit |
| Microbiology (injectables) | |
| Endotoxin | $210 |
| Sterility or bioburden | $150 |
| Container closure integrity (CCI) | $50 |
| Screening | |
| Fentanyl screen | $50 |
10% off for 10 or more samples.
Need something else? Other tests are available on request.
Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.
No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and quantity and LC-MS for identity. Full testing to the USP Valacyclovir Hydrochloride monograph is available and quoted.
Valacyclovir is the L-valine ester of acyclovir, and the ester hydrolyzes in water, faster at higher pH. Acyclovir is the main degradation product and is measured as a separate peak in the purity profile.
Valacyclovir is made with L-valine, and a small amount of the D-valine ester can form. The D-isomer has the same mass and needs a chiral method to separate, which is quoted separately.
Raw material is usually valacyclovir hydrochloride, often as a hydrate. Results can be stated as the salt or as valacyclovir base using the molecular weights.
https://pubchem.ncbi.nlm.nih.gov/compound/135398741
Identity facts from the USP monograph header for this compound.
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