SYN-Coll (Palmitoyl Tripeptide-5)

Palmitoyl Tripeptide-5 is a cosmetic peptide ingredient sold as SYN-Coll: Lys-Val-Lys with a palmitoyl group on the N-terminus.

Palmitoyl Tripeptide-5 testing at Vanguard Laboratory: purity, quantity and identity from $250 per vial, with results in 3 to 5 business days.

Palmitoyl Tripeptide-5 testing packages

Every package includes purity, quantity, identity and a solubility check. Raw powder purity is $200 for a 50 mg sample.

Level 1 Silver

$250

1 vial per sample

Level 2 Gold

$550

3 vials per sample

Level 3 Elite

$700

4 vials per sample

Tests for Palmitoyl Tripeptide-5

Each test can be added to a package or ordered on its own. Results arrive in 3 to 5 business days.

Purity and quantity

Included in every package

How pure the Palmitoyl Tripeptide-5 is and how much is in the vial: purity in area percent, quantity in mg per vial against the label. Details

Conformity icon

Identity

Included in every package

Whether the sample contains Palmitoyl Tripeptide-5, compared with a reference standard. Reported as match or no match. Details

LC-MS identity

Quoted

Whether the molecular mass matches Palmitoyl Tripeptide-5, which helps catch look-alike products. Details

Heavy metals

$150

Lead, arsenic, cadmium, mercury and chromium. Included in Elite. Details

Counterion

$70

How much TFA, acetate or chloride the powder contains. Other salt forms are quoted. Details

Water content

Quoted

How much moisture the powder holds, used to work out the net content. Details

Fentanyl Screen

$50

Runs on the same vial. Included in Elite. Details

TFA Analysis

$50

Available at any level. Details

Vial seal integrity icon

Container Closure Integrity (CCI)

$50

Dye ingress, USP 1207. Available at any level. Details

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Conformity

$100 per extra vial

Vial-to-vial comparison within one lot. Details

Endotoxin

$210

Reported in EU per vial. Included in Gold and Elite. Details

Sterility or Bioburden

$150

Sterility for injectables: 1–10 unopened vials at the same sterility-test price. Bioburden for other forms. Included in Gold and Elite. Details

Residual Solvents

$150

Residual solvent panel. Details

API Purity

$200

Purity for API and raw powders. Details

$200 per vial

Purity and routine identity by retention time and UV spectrum against a reference standard, without quantity: no mg per vial, concentration or label-claim result. 1 vial; 3 to 5 business days. LC-MS is quoted separately. Details

BAC water icon

BAC Water

$200

Benzyl alcohol content and pH. Details

$360 per vial

Screen for semaglutide, tirzepatide and retatrutide without naming the expected peptide. Identity, amount and purity where reportable. Blind GLP-1 panel

Disulfide linkage

Quoted

Which cysteines are paired, by Orbitrap high-resolution mass spectrometry of the digested peptide.

IEX, HILIC and SEC purity

Quoted

Charge, polarity and size variants by ion-exchange, hydrophilic interaction and size-exclusion chromatography, alongside routine HPLC purity.

Conformity icon

Amino acid analysis

Quoted

Hydrolysis and amino acid analysis, to confirm composition and net peptide content.

Conformity icon

Chiral analysis

Quoted

D- and L-forms of the amino acids, to check for racemization.

Orders of ten or more samples are 10% off.

Compound data

Classification

palmitoylated linear tripeptide

Formula

C33H65N5O5

Molecular weight

611.9 g/mol
Monoisotopic 611.50 Da

CAS number

623172-55-4

Sequence, structure and names

Pal-1 Lys · 2 Val · 3 Lys

Modifications: N-terminal palmitoyl group; free C-terminal acid.

Other names: SYN-Coll (trade name), Pal-KVK

How Vanguard tests Palmitoyl Tripeptide-5

Palmitoyl Tripeptide-5 runs on the lab’s peptide purity and quantity method: reversed-phase HPLC on a C18 column with a water and acetonitrile gradient containing 0.1% TFA, and UV detection at 214 to 220 nm. Purity is the main peak’s share of the total peak area, quantity is measured against a reference standard, and identity is confirmed by retention time and UV spectrum against the same standard. LC-MS confirmation of the mass is quoted separately.

In finished creams and serums the peptide is present at low levels and the formula affects extraction, so finished-product assays are quoted; see topicals and cosmetics testing.

What's reported

  • Purity, as percent of total peak area by HPLC-UV
  • Quantity, in mg per vial against the label claim
  • Identity, reported as match or no match against the reference standard
  • On request: mass by LC-MS, counterion content and water content

Salts, forms and compendial references

  • Usually supplied as a lyophilized acetate or TFA salt. Tell us the form the label states, so quantity is reported on the same basis.
  • No official USP-NF monograph for Palmitoyl Tripeptide-5 was found.

Sample amount and turnaround

Send 1 vial or 50 mg of raw powder per sample; for a solution, tell us the claimed concentration. Results arrive in 3 to 5 business days.

Questions about Palmitoyl Tripeptide-5 testing

Do you test the raw peptide or the supplier's solution?

Either. Tell us which, and for a solution the claimed concentration, so quantity is reported on the right basis.

Can you test it in a finished cream or serum?

Yes, as a quoted assay. The peptide is extracted from the formula and measured by HPLC, with the result reported as % w/w or ppm against the label.

Order

Start an order online, or send the compound name and the tests you need for a quote.